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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Secreted Protein/Potential Cytokines.
This gene is a member of the alpha interferon gene cluster on chromosome 9. The encoded cytokine is a member of the type I interferon family that is produced in response to viral infection as a key part of the innate immune response with potent antiviral, antiproliferative and immunomodulatory properties. This cytokine, like other type I interferons, binds a plasma membrane receptor made of IFNAR1 and IFNAR2 that is ubiquitously expressed, and thus is able to act on virtually all body cells. The encoded protein is effective in reducing the symptoms and duration of the common cold and in treating many types of cancer, including some hematological malignancies and solid tumors. A deficiency of type I interferon in the blood is thought to be a hallmark of severe COVID-19 and may provide a rationale for a combined therapeutic approach. [provided by RefSeq, Aug 2020]
| Target ID |
GM-T63934
|
| Target Name |
IFN alpha 2A/IFNA2
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
3440
|
| Gene ID |
3440 (Homo sapiens)
|
| Target Alternative Names |
IFN alpha 2A,IFN-alpha-2,IFN-alphaA,IFNA,IFNA2,IFNA2B,Interferon alpha-2,Interferon alpha-A (LeIF A),leIF A
|
| Uniprot Accession |
P01563
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Category |
Therapeutics Target, Cytokine Target
|
| Disease |
cancer
|
| Disease from KEGG |
Cytokine-cytokine receptor interaction, PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, RIG-I-like receptor signaling pathway, JAK-STAT signaling pathway, Natural killer cell mediated cytotoxicity, Alcoholic liver disease, Tuberculosis, Hepatitis C, Hepatitis B, Measles, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Epstein-Barr virus infection, Pathways in cancer, Autoimmune thyroid disease, Lipid and atherosclerosis
|
| Gene Ensembl |
ENSG00000188379
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of IFN alpha 2A/IFNA2 cDNA Clones/ORF Plasmid
IFN alpha 2A/IFNA2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo3440 | Pre-made Human IFNA2/IFNA/IFNA2B siRNA oligo Duplex | 3440 | Human | In-vitro grade; in-vivo grade | Detail |
IFN alpha 2A/IFNA2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T63934-Ab | Human | Anti-Human IFN alpha 2A/IFNA2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
IFN alpha 2A/IFNA2 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T63934-Ag | Human | Human IFN alpha 2A/IFNA2 recombinant protein | Mammalian cell | Detail |
