Explore SOST/Sclerostin gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Secreted Protein/Potential Cytokines.
Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T60724
|
| Target Name |
SOST/Sclerostin
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
50964
|
| Gene ID |
100065060 (Equus caballus), 101083725 (Felis catus), 282880 (Bos taurus), 490948 (Canis lupus familiaris)
50964 (Homo sapiens), 713617 (Macaca mulatta), 74499 (Mus musculus), 80722 (Rattus norvegicus)
|
| Target Alternative Names |
5430411E23Rik,CDD,DAND6,SOST,SOST1,Sclerostin,Sost,VBCH
|
| Uniprot Accession |
Q9BG79,Q9BQB4,Q99P68,Q99P67
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Category |
Therapeutics Target, INN Index
|
| Disease |
Breast Cancer
|
| Disease from KEGG |
Wnt signaling pathway, Parathyroid hormone synthesis, secretion and action
|
| Gene Ensembl |
ENSECAG00000011911, ENSCAFG00845010604, ENSG00000167941, ENSMMUG00000058522, ENSMUSG00000001494
|
Pre-made viral vector of SOST/Sclerostin cDNA Clones/ORF Plasmid
SOST/Sclerostin siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo50964 | Pre-made Human SOST/CDD/VBCH siRNA oligo Duplex | 50964 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo80722 | Pre-made Rat Sost siRNA oligo Duplex | 80722 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo74499 | Pre-made Mouse Sost/5430411E23Rik siRNA oligo Duplex | 74499 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo713617 | Pre-made Cynomolgus/Rhesus macaque SOST siRNA oligo Duplex | 713617 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101083725 | Pre-made Cat/Feline SOST siRNA oligo Duplex | 101083725 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo490948 | Pre-made Dog/Canine SOST siRNA oligo Duplex | 490948 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo282880 | Pre-made Bovines/Cattle SOST siRNA oligo Duplex | 282880 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100065060 | Pre-made Equine/Horse SOST siRNA oligo Duplex | 100065060 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
SOST/Sclerostin antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T60724-Ab | Human | Anti-Human SOST/Sclerostin monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T60724-Ab | Rat | Anti-Rat SOST/Sclerostin monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T60724-Ab | Mouse | Anti-Mouse SOST/Sclerostin monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T60724-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque SOST/Sclerostin monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T60724-Ab | Cat/Feline | Anti-Cat/Feline SOST/Sclerostin monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T60724-Ab | Dog/Canine | Anti-Dog/Canine SOST/Sclerostin monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T60724-Ab | Bovines/Cattle | Anti-Bovines/Cattle SOST/Sclerostin monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T60724-Ab | Equine/Horse | Anti-Equine/Horse SOST/Sclerostin monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
SOST/Sclerostin recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T60724-Ag | Human | Human SOST/Sclerostin recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T60724-Ag | Rat | Rat SOST/Sclerostin recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T60724-Ag | Mouse | Mouse SOST/Sclerostin recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T60724-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque SOST/Sclerostin recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T60724-Ag | Cat/Feline | Cat/Feline SOST/Sclerostin recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T60724-Ag | Dog/Canine | Dog/Canine SOST/Sclerostin recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T60724-Ag | Bovines/Cattle | Bovines/Cattle SOST/Sclerostin recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T60724-Ag | Equine/Horse | Equine/Horse SOST/Sclerostin recombinant protein | Mammalian cell | Detail |
