Recombinant multi-species SOST/Sclerostin protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine SOST/Sclerostin protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease. [provided by RefSeq, Jul 2008]
The Alternative Names of target: 5430411E23Rik,CDD,DAND6,SOST,SOST1,Sclerostin,Sost,VBCH

Target products collectionGo to SOST/Sclerostin products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T60724-Ag-1/ GM-Tg-hg-T60724-Ag-2 Human SOST/Sclerostin protein Human
GM-Tg-rg-T60724-Ag-1/ GM-Tg-rg-T60724-Ag-2 Rat SOST/Sclerostin protein Rat
GM-Tg-mg-T60724-Ag-1/ GM-Tg-mg-T60724-Ag-2 Mouse SOST/Sclerostin protein Mouse
GM-Tg-cynog-T60724-Ag-1/ GM-Tg-cynog-T60724-Ag-2 Cynomolgus/Rhesus macaque SOST/Sclerostin protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T60724-Ag-1/ GM-Tg-felg-T60724-Ag-2 Feline SOST/Sclerostin protein Feline
GM-Tg-cang-T60724-Ag-1/ GM-Tg-cang-T60724-Ag-2 Canine SOST/Sclerostin protein Canine
GM-Tg-bovg-T60724-Ag-1/ GM-Tg-bovg-T60724-Ag-2 Bovine SOST/Sclerostin protein Bovine
GM-Tg-equg-T60724-Ag-1/ GM-Tg-equg-T60724-Ag-2 Equine SOST/Sclerostin protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T60724-Ag-1/ GM-Tg-hg-T60724-Ag-2; GM-Tg-rg-T60724-Ag-1/ GM-Tg-rg-T60724-Ag-2;
GM-Tg-mg-T60724-Ag-1/ GM-Tg-mg-T60724-Ag-2; GM-Tg-cynog-T60724-Ag-1/ GM-Tg-cynog-T60724-Ag-2;
GM-Tg-felg-T60724-Ag-1/ GM-Tg-felg-T60724-Ag-2; GM-Tg-cang-T60724-Ag-1/ GM-Tg-cang-T60724-Ag-2;
GM-Tg-bovg-T60724-Ag-1/ GM-Tg-bovg-T60724-Ag-2; GM-Tg-equg-T60724-Ag-1/ GM-Tg-equg-T60724-Ag-2
Products Name SOST/Sclerostin protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name SOST/Sclerostin
Protein Sub-location Secreted Protein/Potential Cytokines
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine SOST/Sclerostin protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
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