Explore CASP3/Caspase 3/P17/P19/Cleaved Caspase 3 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Introcelluar Protein.
The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. [provided by RefSeq, Aug 2017]
| Target ID |
GM-T57943
|
| Target Name |
CASP3/Caspase 3/P17/P19/Cleaved Caspase 3
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
836
|
| Gene ID |
100034083 (Equus caballus), 12367 (Mus musculus), 25402 (Rattus norvegicus), 403567 (Canis lupus familiaris)
408016 (Bos taurus), 493932 (Felis catus), 694473 (Macaca mulatta), 836 (Homo sapiens)
|
| Target Alternative Names |
A830040C14Rik,AC-3,Apopain,CASP-3,CASP3,CC3,CPP-32,CPP32,CPP32-beta,CPP32B,Casp3,Caspase 3,Caspase-3,Cleaved Caspase 3,Cysteine protease CPP32 (CPP-32),Lice,P17,P19,Protein Yama,SCA-1,SREBP cleavage activity 1 (SCA-1),Yama,mldy
|
| Uniprot Accession |
P70677,P55213,Q8MKI5,Q08DY9,Q8MJU1,P42574
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer, gastric carcinoma, gastric cancer
|
| Disease from KEGG |
MAPK signaling pathway, p53 signaling pathway, Apoptosis, Apoptosis - multiple species, Natural killer cell mediated cytotoxicity, IL-17 signaling pathway, TNF signaling pathway, Serotonergic synapse, AGE-RAGE signaling pathway in diabetic complications, Alcoholic liver disease, Alzheimer disease, Epithelial cell signaling in Helicobacter pylori infection, Pathogenic Escherichia coli infection, Pertussis, Legionellosis, Toxoplasmosis, Amoebiasis, Tuberculosis, Hepatitis C, Hepatitis B, Measles, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Epstein-Barr virus infection, Pathways in cancer, Proteoglycans in cancer, Colorectal cancer, Small cell lung cancer, Viral myocarditis, Lipid and atherosclerosis
|
| Gene Ensembl |
ENSECAG00000022197, ENSMUSG00000031628, ENSCAFG00845015288, ENSBTAG00000015874, ENSMMUG00000012053, ENSG00000164305
|
Pre-made viral vector of CASP3/Caspase 3/P17/P19/Cleaved Caspase 3 cDNA Clones/ORF Plasmid
CASP3/Caspase 3/P17/P19/Cleaved Caspase 3 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo836 | Pre-made Human CASP3/CPP32/SCA-1 siRNA oligo Duplex | 836 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25402 | Pre-made Rat Casp3/Lice/Yama siRNA oligo Duplex | 25402 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo12367 | Pre-made Mouse Casp3/CC3/AC-3 siRNA oligo Duplex | 12367 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo694473 | Pre-made Cynomolgus/Rhesus macaque CASP3 siRNA oligo Duplex | 694473 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo493932 | Pre-made Cat/Feline CASP3 siRNA oligo Duplex | 493932 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo403567 | Pre-made Dog/Canine CASP3 siRNA oligo Duplex | 403567 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo408016 | Pre-made Bovines/Cattle CASP3 siRNA oligo Duplex | 408016 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100034083 | Pre-made Equine/Horse CASP3 siRNA oligo Duplex | 100034083 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
CASP3/Caspase 3/P17/P19/Cleaved Caspase 3 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T57943-Ab | Human | Anti-Human CASP3/Caspase 3/P17/P19/Cleaved Caspase 3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T57943-Ab | Rat | Anti-Rat CASP3/Caspase 3/P17/P19/Cleaved Caspase 3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T57943-Ab | Mouse | Anti-Mouse CASP3/Caspase 3/P17/P19/Cleaved Caspase 3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T57943-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque CASP3/Caspase 3/P17/P19/Cleaved Caspase 3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T57943-Ab | Cat/Feline | Anti-Cat/Feline CASP3/Caspase 3/P17/P19/Cleaved Caspase 3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T57943-Ab | Dog/Canine | Anti-Dog/Canine CASP3/Caspase 3/P17/P19/Cleaved Caspase 3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T57943-Ab | Bovines/Cattle | Anti-Bovines/Cattle CASP3/Caspase 3/P17/P19/Cleaved Caspase 3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T57943-Ab | Equine/Horse | Anti-Equine/Horse CASP3/Caspase 3/P17/P19/Cleaved Caspase 3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
CASP3/Caspase 3/P17/P19/Cleaved Caspase 3 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T57943-Ag | Human | Human CASP3/Caspase 3/P17/P19/Cleaved Caspase 3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T57943-Ag | Rat | Rat CASP3/Caspase 3/P17/P19/Cleaved Caspase 3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T57943-Ag | Mouse | Mouse CASP3/Caspase 3/P17/P19/Cleaved Caspase 3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T57943-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque CASP3/Caspase 3/P17/P19/Cleaved Caspase 3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T57943-Ag | Cat/Feline | Cat/Feline CASP3/Caspase 3/P17/P19/Cleaved Caspase 3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T57943-Ag | Dog/Canine | Dog/Canine CASP3/Caspase 3/P17/P19/Cleaved Caspase 3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T57943-Ag | Bovines/Cattle | Bovines/Cattle CASP3/Caspase 3/P17/P19/Cleaved Caspase 3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T57943-Ag | Equine/Horse | Equine/Horse CASP3/Caspase 3/P17/P19/Cleaved Caspase 3 recombinant protein | Mammalian cell | Detail |
