Explore CDKN2C gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T45755
|
| Target Name |
CDKN2C
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
1031
|
| Gene ID |
100051195 (Equus caballus), 101086582 (Felis catus), 1031 (Homo sapiens), 12580 (Mus musculus) 475359 (Canis lupus familiaris), 505691 (Bos taurus), 54238 (Rattus norvegicus), 711877 (Macaca mulatta)
|
| Target Alternative Names |
CDKN2C,Cdkn2c,Cyclin-dependent kinase 4 inhibitor C,Cyclin-dependent kinase 6 inhibitor,INK4C,INK4c,p18,p18-INK4C,p18-INK4c,p18-INK6,p18INK4c
|
| Uniprot Accession |
P42773,Q60772
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer, Prostate Cancer
|
| Disease from KEGG |
Endocrine resistance, Cushing syndrome, Human T-cell leukemia virus 1 infection
|
| Gene Ensembl |
ENSECAG00000004817, ENSG00000123080, ENSMUSG00000028551, ENSCAFG00845024510, ENSBTAG00000011059, ENSMMUG00000019057
|
Pre-made viral vector of CDKN2C cDNA Clones/ORF Plasmid
CDKN2C siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo1031 | Pre-made Human CDKN2C/p18/INK4C siRNA oligo Duplex | 1031 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo54238 | Pre-made Rat Cdkn2c/p18 siRNA oligo Duplex | 54238 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo12580 | Pre-made Mouse Cdkn2c/p18/INK4c siRNA oligo Duplex | 12580 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo711877 | Pre-made Cynomolgus/Rhesus macaque CDKN2C siRNA oligo Duplex | 711877 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101086582 | Pre-made Cat/Feline CDKN2C siRNA oligo Duplex | 101086582 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo475359 | Pre-made Dog/Canine CDKN2C siRNA oligo Duplex | 475359 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo505691 | Pre-made Bovines/Cattle CDKN2C siRNA oligo Duplex | 505691 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100051195 | Pre-made Equine/Horse CDKN2C siRNA oligo Duplex | 100051195 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
CDKN2C antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T45755-Ab | Human | Anti-Human CDKN2C monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T45755-Ab | Rat | Anti-Rat CDKN2C monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T45755-Ab | Mouse | Anti-Mouse CDKN2C monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T45755-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque CDKN2C monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T45755-Ab | Cat/Feline | Anti-Cat/Feline CDKN2C monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T45755-Ab | Dog/Canine | Anti-Dog/Canine CDKN2C monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T45755-Ab | Bovines/Cattle | Anti-Bovines/Cattle CDKN2C monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T45755-Ab | Equine/Horse | Anti-Equine/Horse CDKN2C monoclonal antibody | mab | Therapeutics Target antibody | Detail |
CDKN2C recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T45755-Ag | Human | Human CDKN2C recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T45755-Ag | Rat | Rat CDKN2C recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T45755-Ag | Mouse | Mouse CDKN2C recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T45755-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque CDKN2C recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T45755-Ag | Cat/Feline | Cat/Feline CDKN2C recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T45755-Ag | Dog/Canine | Dog/Canine CDKN2C recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T45755-Ag | Bovines/Cattle | Bovines/Cattle CDKN2C recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T45755-Ag | Equine/Horse | Equine/Horse CDKN2C recombinant protein | Mammalian cell | Detail |