Recombinant multi-species CDKN2C protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CDKN2C protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008]
The Alternative Names of target: CDKN2C,Cdkn2c,Cyclin-dependent kinase 4 inhibitor C,Cyclin-dependent kinase 6 inhibitor,INK4C,INK4c,p18,p18-INK4C,p18-INK4c,p18-INK6,p18INK4c

Target products collectionGo to CDKN2C products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T45755-Ag-1/ GM-Tg-hg-T45755-Ag-2 Human CDKN2C protein Human
GM-Tg-rg-T45755-Ag-1/ GM-Tg-rg-T45755-Ag-2 Rat CDKN2C protein Rat
GM-Tg-mg-T45755-Ag-1/ GM-Tg-mg-T45755-Ag-2 Mouse CDKN2C protein Mouse
GM-Tg-cynog-T45755-Ag-1/ GM-Tg-cynog-T45755-Ag-2 Cynomolgus/Rhesus macaque CDKN2C protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T45755-Ag-1/ GM-Tg-felg-T45755-Ag-2 Feline CDKN2C protein Feline
GM-Tg-cang-T45755-Ag-1/ GM-Tg-cang-T45755-Ag-2 Canine CDKN2C protein Canine
GM-Tg-bovg-T45755-Ag-1/ GM-Tg-bovg-T45755-Ag-2 Bovine CDKN2C protein Bovine
GM-Tg-equg-T45755-Ag-1/ GM-Tg-equg-T45755-Ag-2 Equine CDKN2C protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T45755-Ag-1/ GM-Tg-hg-T45755-Ag-2; GM-Tg-rg-T45755-Ag-1/ GM-Tg-rg-T45755-Ag-2;
GM-Tg-mg-T45755-Ag-1/ GM-Tg-mg-T45755-Ag-2; GM-Tg-cynog-T45755-Ag-1/ GM-Tg-cynog-T45755-Ag-2;
GM-Tg-felg-T45755-Ag-1/ GM-Tg-felg-T45755-Ag-2; GM-Tg-cang-T45755-Ag-1/ GM-Tg-cang-T45755-Ag-2;
GM-Tg-bovg-T45755-Ag-1/ GM-Tg-bovg-T45755-Ag-2; GM-Tg-equg-T45755-Ag-1/ GM-Tg-equg-T45755-Ag-2
Products Name CDKN2C protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name CDKN2C
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CDKN2C protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.