Explore NME1/NM23-H1 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Secreted Protein/Potential Cytokines.
This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T42533
|
| Target Name |
NME1/NM23-H1
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
4830
|
| Gene ID |
100533956 (Macaca mulatta), 100533966 (Equus caballus), 101088196 (Felis catus), 4830 (Homo sapiens)
|
| Target Alternative Names |
AWD,GAAD,Granzyme A-activated DNase (GAAD),Metastasis inhibition factor nm23,NB,NBS,NDK A,NDKA,NDP kinase A,NDPK-A,NDPKA,NM23,NM23-H1,NME1,Nucleoside diphosphate kinase A,Tumor metastatic process-associated protein
|
| Uniprot Accession |
P15531
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
Metabolic pathways
|
| Gene Ensembl |
ENSMMUG00000001940, ENSECAG00000059404, ENSG00000239672
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of NME1/NM23-H1 cDNA Clones/ORF Plasmid
NME1/NM23-H1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo4830 | Pre-made Human NME1/NB/AWD siRNA oligo Duplex | 4830 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100533956 | Pre-made Cynomolgus/Rhesus macaque NME1 siRNA oligo Duplex | 100533956 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101088196 | Pre-made Cat/Feline NME1 siRNA oligo Duplex | 101088196 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100533966 | Pre-made Equine/Horse NME1 siRNA oligo Duplex | 100533966 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
NME1/NM23-H1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T42533-Ab | Human | Anti-Human NME1/NM23-H1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T42533-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque NME1/NM23-H1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T42533-Ab | Cat/Feline | Anti-Cat/Feline NME1/NM23-H1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T42533-Ab | Equine/Horse | Anti-Equine/Horse NME1/NM23-H1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
NME1/NM23-H1 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T42533-Ag | Human | Human NME1/NM23-H1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T42533-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque NME1/NM23-H1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T42533-Ag | Cat/Feline | Cat/Feline NME1/NM23-H1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T42533-Ag | Equine/Horse | Equine/Horse NME1/NM23-H1 recombinant protein | Mammalian cell | Detail |
