Explore TNFSF15 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
| Target ID |
GM-T35212
|
| Target Name |
TNFSF15
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
9966
|
| Gene ID |
100049906 (Equus caballus), 101099505 (Felis catus), 252878 (Rattus norvegicus), 326623 (Mus musculus)
481688 (Canis lupus familiaris), 514239 (Bos taurus), 703189 (Macaca mulatta), 9966 (Homo sapiens)
|
| Target Alternative Names |
TL1,TL1A,TNF ligand-related molecule 1,TNFSF15,TNLG1B,Tl1,Tl1a,Tnfsf15,Tnlg1b,Tumor necrosis factor ligand superfamily member 15,VEGI,VEGI192A,Vascular endothelial cell growth inhibitor,Vegi
|
| Uniprot Accession |
Q8K3Y7,Q5UBV8,O95150
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, Cytokine Target
|
| Disease |
cancer
|
| Disease from KEGG |
Cytokine-cytokine receptor interaction
|
| Gene Ensembl |
ENSECAG00000014513, ENSMUSG00000050395, ENSBTAG00000018069, ENSMMUG00000012892, ENSG00000181634
|
Pre-made viral vector of TNFSF15 cDNA Clones/ORF Plasmid
TNFSF15 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo9966 | Pre-made Human TNFSF15/TL1/TL1A siRNA oligo Duplex | 9966 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo252878 | Pre-made Rat Tnfsf15/Tnlg1b siRNA oligo Duplex | 252878 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo326623 | Pre-made Mouse Tnfsf15/Tl1/Tl1a siRNA oligo Duplex | 326623 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo703189 | Pre-made Cynomolgus/Rhesus macaque TNFSF15/TNLG1B siRNA oligo Duplex | 703189 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101099505 | Pre-made Cat/Feline TNFSF15 siRNA oligo Duplex | 101099505 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo481688 | Pre-made Dog/Canine TNFSF15 siRNA oligo Duplex | 481688 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo514239 | Pre-made Bovines/Cattle TNFSF15/TNLG1B siRNA oligo Duplex | 514239 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100049906 | Pre-made Equine/Horse TNFSF15/TNLG1B siRNA oligo Duplex | 100049906 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
TNFSF15 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T35212-Ab | Human | Anti-Human TNFSF15 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-rg-T35212-Ab | Rat | Anti-Rat TNFSF15 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-mg-T35212-Ab | Mouse | Anti-Mouse TNFSF15 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cynog-T35212-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque TNFSF15 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-felg-T35212-Ab | Cat/Feline | Anti-Cat/Feline TNFSF15 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cang-T35212-Ab | Dog/Canine | Anti-Dog/Canine TNFSF15 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-bovg-T35212-Ab | Bovines/Cattle | Anti-Bovines/Cattle TNFSF15 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-equg-T35212-Ab | Equine/Horse | Anti-Equine/Horse TNFSF15 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
TNFSF15 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T35212-Ag | Human | Human TNFSF15 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T35212-Ag | Rat | Rat TNFSF15 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T35212-Ag | Mouse | Mouse TNFSF15 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T35212-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque TNFSF15 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T35212-Ag | Cat/Feline | Cat/Feline TNFSF15 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T35212-Ag | Dog/Canine | Dog/Canine TNFSF15 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T35212-Ag | Bovines/Cattle | Bovines/Cattle TNFSF15 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T35212-Ag | Equine/Horse | Equine/Horse TNFSF15 VLP (virus-like particle) | HEK293 | Products Developing |
