Explore GDF15 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Secreted Protein/Potential Cytokines.
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The protein is expressed in a broad range of cell types, acts as a pleiotropic cytokine and is involved in the stress response program of cells after cellular injury. Increased protein levels are associated with disease states such as tissue hypoxia, inflammation, acute injury and oxidative stress. [provided by RefSeq, Aug 2016]
| Target ID |
GM-T33245
|
| Target Name |
GDF15
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
9518
|
| Gene ID |
101086633 (Felis catus), 111769675 (Equus caballus), 23886 (Mus musculus), 29455 (Rattus norvegicus)
484822 (Canis lupus familiaris), 618677 (Bos taurus), 719466 (Macaca mulatta), 9518 (Homo sapiens)
|
| Target Alternative Names |
GDF-15,GDF15,Gdf15,Growth/differentiation factor 15,HG,MIC-1,MIC1,Macrophage inhibitory cytokine 1 (MIC-1),NAG-1,NSAID-activated gene 1 protein (NAG-1),NSAID-regulated gene 1 protein (NRG-1),PDF,PLAB,PTGFB,Placental TGF-beta,Placental bone morphogenetic protein,Prostate differentiation factor,SBF
|
| Uniprot Accession |
Q9Z0J7,Q9Z0J6,Q99988
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Category |
Therapeutics Target, Diagnostics Biomarker, INN Index, Cytokine Target
|
| Disease |
cancer, Ovary Cancer
|
| Disease from KEGG |
Cytokine-cytokine receptor interaction
|
| Gene Ensembl |
ENSECAG00000039579, ENSMUSG00000038508, ENSCAFG00845022411, ENSBTAG00000015618, ENSMMUG00000050122, ENSG00000130513
|
Pre-made viral vector of GDF15 cDNA Clones/ORF Plasmid
GDF15 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo9518 | Pre-made Human GDF15/HG/PDF siRNA oligo Duplex | 9518 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo29455 | Pre-made Rat Gdf15 siRNA oligo Duplex | 29455 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo23886 | Pre-made Mouse Gdf15/SBF/MIC-1 siRNA oligo Duplex | 23886 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo719466 | Pre-made Cynomolgus/Rhesus macaque GDF15 siRNA oligo Duplex | 719466 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101086633 | Pre-made Cat/Feline GDF15 siRNA oligo Duplex | 101086633 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo484822 | Pre-made Dog/Canine GDF15 siRNA oligo Duplex | 484822 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo618677 | Pre-made Bovines/Cattle GDF15 siRNA oligo Duplex | 618677 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo111769675 | Pre-made Equine/Horse GDF15 siRNA oligo Duplex | 111769675 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
GDF15 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T33245-Ab | Human | Anti-Human GDF15 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody, Cytokine antibody | Detail |
| GM-Tg-rg-T33245-Ab | Rat | Anti-Rat GDF15 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody, Cytokine antibody | Detail |
| GM-Tg-mg-T33245-Ab | Mouse | Anti-Mouse GDF15 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody, Cytokine antibody | Detail |
| GM-Tg-cynog-T33245-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque GDF15 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody, Cytokine antibody | Detail |
| GM-Tg-felg-T33245-Ab | Cat/Feline | Anti-Cat/Feline GDF15 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody, Cytokine antibody | Detail |
| GM-Tg-cang-T33245-Ab | Dog/Canine | Anti-Dog/Canine GDF15 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody, Cytokine antibody | Detail |
| GM-Tg-bovg-T33245-Ab | Bovines/Cattle | Anti-Bovines/Cattle GDF15 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody, Cytokine antibody | Detail |
| GM-Tg-equg-T33245-Ab | Equine/Horse | Anti-Equine/Horse GDF15 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody, Cytokine antibody | Detail |
GDF15 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T33245-Ag | Human | Human GDF15 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T33245-Ag | Rat | Rat GDF15 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T33245-Ag | Mouse | Mouse GDF15 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T33245-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque GDF15 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T33245-Ag | Cat/Feline | Cat/Feline GDF15 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T33245-Ag | Dog/Canine | Dog/Canine GDF15 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T33245-Ag | Bovines/Cattle | Bovines/Cattle GDF15 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T33245-Ag | Equine/Horse | Equine/Horse GDF15 recombinant protein | Mammalian cell | Detail |
