Recombinant multi-species GDF15 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine GDF15 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The protein is expressed in a broad range of cell types, acts as a pleiotropic cytokine and is involved in the stress response program of cells after cellular injury. Increased protein levels are associated with disease states such as tissue hypoxia, inflammation, acute injury and oxidative stress. [provided by RefSeq, Aug 2016]
The Alternative Names of target: GDF-15,GDF15,Gdf15,Growth/differentiation factor 15,HG,MIC-1,MIC1,Macrophage inhibitory cytokine 1 (MIC-1),NAG-1,NSAID-activated gene 1 protein (NAG-1),NSAID-regulated gene 1 protein (NRG-1),PDF,PLAB,PTGFB,Placental TGF-beta,Placental bone morphogenetic protein,Prostate differentiation factor,SBF

Target products collectionGo to GDF15 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T33245-Ag-1/ GM-Tg-hg-T33245-Ag-2 Human GDF15 protein Human
GM-Tg-rg-T33245-Ag-1/ GM-Tg-rg-T33245-Ag-2 Rat GDF15 protein Rat
GM-Tg-mg-T33245-Ag-1/ GM-Tg-mg-T33245-Ag-2 Mouse GDF15 protein Mouse
GM-Tg-cynog-T33245-Ag-1/ GM-Tg-cynog-T33245-Ag-2 Cynomolgus/Rhesus macaque GDF15 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T33245-Ag-1/ GM-Tg-felg-T33245-Ag-2 Feline GDF15 protein Feline
GM-Tg-cang-T33245-Ag-1/ GM-Tg-cang-T33245-Ag-2 Canine GDF15 protein Canine
GM-Tg-bovg-T33245-Ag-1/ GM-Tg-bovg-T33245-Ag-2 Bovine GDF15 protein Bovine
GM-Tg-equg-T33245-Ag-1/ GM-Tg-equg-T33245-Ag-2 Equine GDF15 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T33245-Ag-1/ GM-Tg-hg-T33245-Ag-2; GM-Tg-rg-T33245-Ag-1/ GM-Tg-rg-T33245-Ag-2;
GM-Tg-mg-T33245-Ag-1/ GM-Tg-mg-T33245-Ag-2; GM-Tg-cynog-T33245-Ag-1/ GM-Tg-cynog-T33245-Ag-2;
GM-Tg-felg-T33245-Ag-1/ GM-Tg-felg-T33245-Ag-2; GM-Tg-cang-T33245-Ag-1/ GM-Tg-cang-T33245-Ag-2;
GM-Tg-bovg-T33245-Ag-1/ GM-Tg-bovg-T33245-Ag-2; GM-Tg-equg-T33245-Ag-1/ GM-Tg-equg-T33245-Ag-2
Products Name GDF15 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name GDF15
Protein Sub-location Secreted Protein/Potential Cytokines
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine GDF15 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

    GDU
    GDU

    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.