Explore TK1 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Introcelluar Protein.
The protein encoded by this gene is a cytosolic enzyme that catalyzes the addition of a gamma-phosphate group to thymidine. This creates dTMP and is the first step in the biosynthesis of dTTP, which is one component required for DNA replication. The encoded protein, whose levels fluctuate depending on the cell cycle stage, can act as a low activity dimer or a high activity tetramer. High levels of this protein have been used as a biomarker for diagnosing and categorizing many types of cancers. [provided by RefSeq, Oct 2016]
| Target ID |
GM-T30081
|
| Target Name |
TK1
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
7083
|
| Gene ID |
100057908 (Equus caballus), 100855947 (Canis lupus familiaris), 101101270 (Felis catus), 21877 (Mus musculus)
24834 (Rattus norvegicus), 504652 (Bos taurus), 7083 (Homo sapiens), 709403 (Macaca mulatta)
|
| Target Alternative Names |
D530002A18Rik,TK1,TK2,Thymidine kinase,Tk,Tk-1,Tk1,Tk1a,Tk1b,cytosolic
|
| Uniprot Accession |
P04184,P27158,A5D7R8,P04183
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target, Diagnostics Biomarker, Immuno-oncology Target
|
| Disease from KEGG |
Metabolic pathways
|
| Gene Ensembl |
ENSECAG00000016173, ENSCAFG00845014848, ENSMUSG00000025574, ENSBTAG00000007121, ENSG00000167900
|
| Target Classification |
Checkpoint-Immuno Oncology
|
Pre-made viral vector of TK1 cDNA Clones/ORF Plasmid
TK1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo7083 | Pre-made Human TK1/TK2 siRNA oligo Duplex | 7083 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo24834 | Pre-made Rat Tk1/Tk siRNA oligo Duplex | 24834 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo21877 | Pre-made Mouse Tk1/Tk-1/Tk1a siRNA oligo Duplex | 21877 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo709403 | Pre-made Cynomolgus/Rhesus macaque TK1 siRNA oligo Duplex | 709403 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101101270 | Pre-made Cat/Feline TK1 siRNA oligo Duplex | 101101270 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100855947 | Pre-made Dog/Canine TK1 siRNA oligo Duplex | 100855947 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo504652 | Pre-made Bovines/Cattle TK1 siRNA oligo Duplex | 504652 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100057908 | Pre-made Equine/Horse TK1 siRNA oligo Duplex | 100057908 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
TK1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T30081-Ab | Human | Anti-Human TK1 monoclonal antibody | mab | Therapeutics Target antibody, Diagnostic target antibody | Detail |
| GM-Tg-rg-T30081-Ab | Rat | Anti-Rat TK1 monoclonal antibody | mab | Therapeutics Target antibody, Diagnostic target antibody | Detail |
| GM-Tg-mg-T30081-Ab | Mouse | Anti-Mouse TK1 monoclonal antibody | mab | Therapeutics Target antibody, Diagnostic target antibody | Detail |
| GM-Tg-cynog-T30081-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque TK1 monoclonal antibody | mab | Therapeutics Target antibody, Diagnostic target antibody | Detail |
| GM-Tg-felg-T30081-Ab | Cat/Feline | Anti-Cat/Feline TK1 monoclonal antibody | mab | Therapeutics Target antibody, Diagnostic target antibody | Detail |
| GM-Tg-cang-T30081-Ab | Dog/Canine | Anti-Dog/Canine TK1 monoclonal antibody | mab | Therapeutics Target antibody, Diagnostic target antibody | Detail |
| GM-Tg-bovg-T30081-Ab | Bovines/Cattle | Anti-Bovines/Cattle TK1 monoclonal antibody | mab | Therapeutics Target antibody, Diagnostic target antibody | Detail |
| GM-Tg-equg-T30081-Ab | Equine/Horse | Anti-Equine/Horse TK1 monoclonal antibody | mab | Therapeutics Target antibody, Diagnostic target antibody | Detail |
TK1 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T30081-Ag | Human | Human TK1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T30081-Ag | Rat | Rat TK1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T30081-Ag | Mouse | Mouse TK1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T30081-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque TK1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T30081-Ag | Cat/Feline | Cat/Feline TK1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T30081-Ag | Dog/Canine | Dog/Canine TK1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T30081-Ag | Bovines/Cattle | Bovines/Cattle TK1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T30081-Ag | Equine/Horse | Equine/Horse TK1 recombinant protein | Mammalian cell | Detail |
