Explore GAD1 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T26900
|
| Target Name |
GAD1
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
2571
|
| Gene ID |
100052860 (Equus caballus), 14415 (Mus musculus), 24379 (Rattus norvegicus), 2571 (Homo sapiens) 478794 (Canis lupus familiaris), 493699 (Felis catus), 517552 (Bos taurus), 613030 (Macaca mulatta)
|
| Target Alternative Names |
67 kDa glutamic acid decarboxylase (GAD-67),CPSQ1,DEE89,EP10,GAD,GAD1,GAD67,Gad-1,Gad1,Gad67,Glutamate decarboxylase 1,Glutamate decarboxylase 67 kDa isoform,SCP
|
| Uniprot Accession |
P48318,P18088,Q99259,A0PA85,P14748,Q0VCA1
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
Metabolic pathways, GABAergic synapse, Type I diabetes mellitus
|
| Gene Ensembl |
ENSECAG00000012405, ENSMUSG00000070880, ENSG00000128683, ENSCAFG00845025996, ENSBTAG00000007258, ENSMMUG00000015198
|
Pre-made viral vector of GAD1 cDNA Clones/ORF Plasmid
GAD1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo2571 | Pre-made Human GAD1/GAD/SCP siRNA oligo Duplex | 2571 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo24379 | Pre-made Rat Gad1/Gad67 siRNA oligo Duplex | 24379 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo14415 | Pre-made Mouse Gad1/EP10/Gad-1 siRNA oligo Duplex | 14415 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo613030 | Pre-made Cynomolgus/Rhesus macaque GAD1/GAD67 siRNA oligo Duplex | 613030 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo493699 | Pre-made Cat/Feline GAD1/GAD67 siRNA oligo Duplex | 493699 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo478794 | Pre-made Dog/Canine GAD1/GAD67 siRNA oligo Duplex | 478794 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo517552 | Pre-made Bovines/Cattle GAD1 siRNA oligo Duplex | 517552 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100052860 | Pre-made Equine/Horse GAD1 siRNA oligo Duplex | 100052860 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
GAD1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T26900-Ab | Human | Anti-Human GAD1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T26900-Ab | Rat | Anti-Rat GAD1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T26900-Ab | Mouse | Anti-Mouse GAD1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T26900-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque GAD1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T26900-Ab | Cat/Feline | Anti-Cat/Feline GAD1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T26900-Ab | Dog/Canine | Anti-Dog/Canine GAD1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T26900-Ab | Bovines/Cattle | Anti-Bovines/Cattle GAD1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T26900-Ab | Equine/Horse | Anti-Equine/Horse GAD1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
GAD1 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T26900-Ag | Human | Human GAD1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T26900-Ag | Rat | Rat GAD1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T26900-Ag | Mouse | Mouse GAD1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T26900-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque GAD1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T26900-Ag | Cat/Feline | Cat/Feline GAD1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T26900-Ag | Dog/Canine | Dog/Canine GAD1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T26900-Ag | Bovines/Cattle | Bovines/Cattle GAD1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T26900-Ag | Equine/Horse | Equine/Horse GAD1 recombinant protein | Mammalian cell | Detail |