Recombinant multi-species GAD1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine GAD1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form. [provided by RefSeq, Jul 2008]
The Alternative Names of target: 67 kDa glutamic acid decarboxylase (GAD-67),CPSQ1,DEE89,EP10,GAD,GAD1,GAD67,Gad-1,Gad1,Gad67,Glutamate decarboxylase 1,Glutamate decarboxylase 67 kDa isoform,SCP

Target products collectionGo to GAD1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T26900-Ag-1/ GM-Tg-hg-T26900-Ag-2 Human GAD1 protein Human
GM-Tg-rg-T26900-Ag-1/ GM-Tg-rg-T26900-Ag-2 Rat GAD1 protein Rat
GM-Tg-mg-T26900-Ag-1/ GM-Tg-mg-T26900-Ag-2 Mouse GAD1 protein Mouse
GM-Tg-cynog-T26900-Ag-1/ GM-Tg-cynog-T26900-Ag-2 Cynomolgus/Rhesus macaque GAD1 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T26900-Ag-1/ GM-Tg-felg-T26900-Ag-2 Feline GAD1 protein Feline
GM-Tg-cang-T26900-Ag-1/ GM-Tg-cang-T26900-Ag-2 Canine GAD1 protein Canine
GM-Tg-bovg-T26900-Ag-1/ GM-Tg-bovg-T26900-Ag-2 Bovine GAD1 protein Bovine
GM-Tg-equg-T26900-Ag-1/ GM-Tg-equg-T26900-Ag-2 Equine GAD1 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T26900-Ag-1/ GM-Tg-hg-T26900-Ag-2; GM-Tg-rg-T26900-Ag-1/ GM-Tg-rg-T26900-Ag-2;
GM-Tg-mg-T26900-Ag-1/ GM-Tg-mg-T26900-Ag-2; GM-Tg-cynog-T26900-Ag-1/ GM-Tg-cynog-T26900-Ag-2;
GM-Tg-felg-T26900-Ag-1/ GM-Tg-felg-T26900-Ag-2; GM-Tg-cang-T26900-Ag-1/ GM-Tg-cang-T26900-Ag-2;
GM-Tg-bovg-T26900-Ag-1/ GM-Tg-bovg-T26900-Ag-2; GM-Tg-equg-T26900-Ag-1/ GM-Tg-equg-T26900-Ag-2
Products Name GAD1 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name GAD1
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine GAD1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
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