Explore Endothelin 1/EDN1 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Secreted Protein/Potential Cytokines.
This gene encodes a preproprotein that is proteolytically processed to generate a secreted peptide that belongs to the endothelin/sarafotoxin family. This peptide is a potent vasoconstrictor and its cognate receptors are therapeutic targets in the treatment of pulmonary arterial hypertension. Aberrant expression of this gene may promote tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
| Target ID |
GM-T25076
|
| Target Name |
Endothelin 1/EDN1
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
1906
|
| Gene ID |
100034060 (Equus caballus), 13614 (Mus musculus), 1906 (Homo sapiens), 24323 (Rattus norvegicus)
281137 (Bos taurus), 403424 (Canis lupus familiaris), 494214 (Felis catus), 699982 (Macaca mulatta)
|
| Target Alternative Names |
ARCND3,EDN1,ET-1,ET1,Edn1,Endothelin 1,Endothelin-1,Et1,HDLCQ7,PPET1,Preproendothelin-1 (PPET1),QME,preproET
|
| Uniprot Accession |
P22387,P05305,P22388,P17322,P13206,Q5NRQ1
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
cAMP signaling pathway, HIF-1 signaling pathway, Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction, TNF signaling pathway, Melanogenesis, Renin secretion, Relaxin signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Pathways in cancer, Hypertrophic cardiomyopathy, Fluid shear stress and atherosclerosis
|
| Gene Ensembl |
ENSECAG00000011618, ENSMUSG00000021367, ENSG00000078401, ENSBTAG00000008096, ENSCAFG00845021350, ENSMMUG00000051532
|
Pre-made viral vector of Endothelin 1/EDN1 cDNA Clones/ORF Plasmid
Endothelin 1/EDN1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo1906 | Pre-made Human EDN1/ET1/QME siRNA oligo Duplex | 1906 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo24323 | Pre-made Rat Edn1/Et1 siRNA oligo Duplex | 24323 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo13614 | Pre-made Mouse Edn1/ET-1/PPET1 siRNA oligo Duplex | 13614 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo699982 | Pre-made Cynomolgus/Rhesus macaque EDN1 siRNA oligo Duplex | 699982 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo494214 | Pre-made Cat/Feline EDN1/ET-1 siRNA oligo Duplex | 494214 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo403424 | Pre-made Dog/Canine EDN1/PPET1 siRNA oligo Duplex | 403424 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo281137 | Pre-made Bovines/Cattle EDN1 siRNA oligo Duplex | 281137 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100034060 | Pre-made Equine/Horse EDN1 siRNA oligo Duplex | 100034060 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
Endothelin 1/EDN1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T25076-Ab | Human | Anti-Human Endothelin 1/EDN1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T25076-Ab | Rat | Anti-Rat Endothelin 1/EDN1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T25076-Ab | Mouse | Anti-Mouse Endothelin 1/EDN1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T25076-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque Endothelin 1/EDN1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T25076-Ab | Cat/Feline | Anti-Cat/Feline Endothelin 1/EDN1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T25076-Ab | Dog/Canine | Anti-Dog/Canine Endothelin 1/EDN1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T25076-Ab | Bovines/Cattle | Anti-Bovines/Cattle Endothelin 1/EDN1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T25076-Ab | Equine/Horse | Anti-Equine/Horse Endothelin 1/EDN1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
Endothelin 1/EDN1 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T25076-Ag | Human | Human Endothelin 1/EDN1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T25076-Ag | Rat | Rat Endothelin 1/EDN1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T25076-Ag | Mouse | Mouse Endothelin 1/EDN1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T25076-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque Endothelin 1/EDN1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T25076-Ag | Cat/Feline | Cat/Feline Endothelin 1/EDN1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T25076-Ag | Dog/Canine | Dog/Canine Endothelin 1/EDN1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T25076-Ag | Bovines/Cattle | Bovines/Cattle Endothelin 1/EDN1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T25076-Ag | Equine/Horse | Equine/Horse Endothelin 1/EDN1 recombinant protein | Mammalian cell | Detail |
