Recombinant multi-species Endothelin 1/EDN1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine Endothelin 1/EDN1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a preproprotein that is proteolytically processed to generate a secreted peptide that belongs to the endothelin/sarafotoxin family. This peptide is a potent vasoconstrictor and its cognate receptors are therapeutic targets in the treatment of pulmonary arterial hypertension. Aberrant expression of this gene may promote tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
The Alternative Names of target: ARCND3,EDN1,ET-1,ET1,Edn1,Endothelin 1,Endothelin-1,Et1,HDLCQ7,PPET1,Preproendothelin-1 (PPET1),QME,preproET

Target products collectionGo to Endothelin 1/EDN1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T25076-Ag-1/ GM-Tg-hg-T25076-Ag-2 Human Endothelin 1/EDN1 protein Human
GM-Tg-rg-T25076-Ag-1/ GM-Tg-rg-T25076-Ag-2 Rat Endothelin 1/EDN1 protein Rat
GM-Tg-mg-T25076-Ag-1/ GM-Tg-mg-T25076-Ag-2 Mouse Endothelin 1/EDN1 protein Mouse
GM-Tg-cynog-T25076-Ag-1/ GM-Tg-cynog-T25076-Ag-2 Cynomolgus/Rhesus macaque Endothelin 1/EDN1 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T25076-Ag-1/ GM-Tg-felg-T25076-Ag-2 Feline Endothelin 1/EDN1 protein Feline
GM-Tg-cang-T25076-Ag-1/ GM-Tg-cang-T25076-Ag-2 Canine Endothelin 1/EDN1 protein Canine
GM-Tg-bovg-T25076-Ag-1/ GM-Tg-bovg-T25076-Ag-2 Bovine Endothelin 1/EDN1 protein Bovine
GM-Tg-equg-T25076-Ag-1/ GM-Tg-equg-T25076-Ag-2 Equine Endothelin 1/EDN1 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T25076-Ag-1/ GM-Tg-hg-T25076-Ag-2; GM-Tg-rg-T25076-Ag-1/ GM-Tg-rg-T25076-Ag-2;
GM-Tg-mg-T25076-Ag-1/ GM-Tg-mg-T25076-Ag-2; GM-Tg-cynog-T25076-Ag-1/ GM-Tg-cynog-T25076-Ag-2;
GM-Tg-felg-T25076-Ag-1/ GM-Tg-felg-T25076-Ag-2; GM-Tg-cang-T25076-Ag-1/ GM-Tg-cang-T25076-Ag-2;
GM-Tg-bovg-T25076-Ag-1/ GM-Tg-bovg-T25076-Ag-2; GM-Tg-equg-T25076-Ag-1/ GM-Tg-equg-T25076-Ag-2
Products Name Endothelin 1/EDN1 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name Endothelin 1/EDN1
Protein Sub-location Secreted Protein/Potential Cytokines
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine Endothelin 1/EDN1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

    GDU
    GDU

    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.