Explore oncostatin M/OSM gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Secreted Protein/Potential Cytokines.
This gene encodes a member of the leukemia inhibitory factor/oncostatin-M (LIF/OSM) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a secreted cytokine and growth regulator that inhibits the proliferation of a number of tumor cell lines. This protein also regulates the production of other cytokines, including interleukin 6, granulocyte-colony stimulating factor and granulocyte-macrophage colony stimulating factor in endothelial cells. This gene and the related gene, leukemia inhibitory factor, also present on chromosome 22, may have resulted from the duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
| Target ID |
GM-T19556
|
| Target Name |
oncostatin M/OSM
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
5008
|
| Gene ID |
100064031 (Equus caballus), 101094379 (Felis catus), 18413 (Mus musculus), 289747 (Rattus norvegicus) 319086 (Bos taurus), 5008 (Homo sapiens), 611921 (Canis lupus familiaris), 717994 (Macaca mulatta)
|
| Target Alternative Names |
OSM,OncoM,Oncostatin-M,Osm,oncostatin M
|
| Uniprot Accession |
P53347,Q65Z15,P53346,P13725
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Category |
Therapeutics Target, Cytokine Target
|
| Disease from KEGG |
Cytokine-cytokine receptor interaction, PI3K-Akt signaling pathway, JAK-STAT signaling pathway
|
| Gene Ensembl |
ENSECAG00000042076, ENSMUSG00000058755, ENSBTAG00000016163, ENSG00000099985, ENSCAFG00845030908, ENSMMUG00000005545
|
Pre-made viral vector of oncostatin M/OSM cDNA Clones/ORF Plasmid
oncostatin M/OSM siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo5008 | Pre-made Human OSM siRNA oligo Duplex | 5008 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo289747 | Pre-made Rat Osm siRNA oligo Duplex | 289747 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo18413 | Pre-made Mouse Osm/OncoM siRNA oligo Duplex | 18413 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo717994 | Pre-made Cynomolgus/Rhesus macaque OSM siRNA oligo Duplex | 717994 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101094379 | Pre-made Cat/Feline OSM siRNA oligo Duplex | 101094379 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo611921 | Pre-made Dog/Canine OSM siRNA oligo Duplex | 611921 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo319086 | Pre-made Bovines/Cattle OSM siRNA oligo Duplex | 319086 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100064031 | Pre-made Equine/Horse OSM siRNA oligo Duplex | 100064031 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
oncostatin M/OSM antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T19556-Ab | Human | Anti-Human oncostatin M/OSM monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-rg-T19556-Ab | Rat | Anti-Rat oncostatin M/OSM monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-mg-T19556-Ab | Mouse | Anti-Mouse oncostatin M/OSM monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cynog-T19556-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque oncostatin M/OSM monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-felg-T19556-Ab | Cat/Feline | Anti-Cat/Feline oncostatin M/OSM monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cang-T19556-Ab | Dog/Canine | Anti-Dog/Canine oncostatin M/OSM monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-bovg-T19556-Ab | Bovines/Cattle | Anti-Bovines/Cattle oncostatin M/OSM monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-equg-T19556-Ab | Equine/Horse | Anti-Equine/Horse oncostatin M/OSM monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
oncostatin M/OSM recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T19556-Ag | Human | Human oncostatin M/OSM recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T19556-Ag | Rat | Rat oncostatin M/OSM recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T19556-Ag | Mouse | Mouse oncostatin M/OSM recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T19556-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque oncostatin M/OSM recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T19556-Ag | Cat/Feline | Cat/Feline oncostatin M/OSM recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T19556-Ag | Dog/Canine | Dog/Canine oncostatin M/OSM recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T19556-Ag | Bovines/Cattle | Bovines/Cattle oncostatin M/OSM recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T19556-Ag | Equine/Horse | Equine/Horse oncostatin M/OSM recombinant protein | Mammalian cell | Detail |