DHFR Target & Gene Products-cDNA ORF clones/siRNA/antibody/protein

Explore DHFR gene products and cross-species research data at TarMart platform. Discover comprehensive biological information, expression tools, and therapeutic insights for Homo sapiens (human), Cynomolgus monkeys, rodents (mouse/rat), canines, felines, bovines, and equines. Your premier destination for multi-species gene research solutions
Target sublocation: Introcelluar Protein.
Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the functional dihydrofolate reductase gene has been mapped to chromosome 5, multiple intronless processed pseudogenes or dihydrofolate reductase-like genes have been identified on separate chromosomes. Dihydrofolate reductase deficiency has been linked to megaloblastic anemia. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2014]

Target ID	GM-T17345
Target Name	DHFR
Gene Group ldentifer （Target Gene ID in Homo species)	1719
Gene ID	100073256 (Equus caballus), 101087964 (Felis catus), 13361 (Mus musculus), 1719 (Homo sapiens) 24312 (Rattus norvegicus), 479165 (Canis lupus familiaris), 508809 (Bos taurus), 711268 (Macaca mulatta)
Target Alternative Names	8430436I03Rik,DHFR,DHFR1,DHFRP1,DYR,Dhfr,Dhfr1,Dihydrofolate reductase
Uniprot Accession	P00375,P00374,Q920D2,P00376
Protein Sub-location	Introcelluar Protein
Category	Therapeutics Target
Disease	cancer
Disease from KEGG	Metabolic pathways, Antifolate resistance
Gene Ensembl	ENSECAG00000026827, ENSMUSG00000021707, ENSG00000228716, ENSCAFG00845005830, ENSBTAG00000007681, ENSMMUG00000018283
Target Classification	Tumor-associated antigen (TAA)

Pre-made viral vector of DHFR cDNA Clones/ORF Plasmid

Cat No.	Product Name	NMID	GeneID	Species	Type	Marker	Fusion Tag	Promoter	Detail
pGMLP000510	Human DHFR/DHFRP1/DYR Lentivirus plasmid	NM_000791	1719	Human	Lentivirus plasmid	ZsGreen	3xflag (C-Terminal)	CMV	Detail
pGMAP000102	Human DHFR Adenovirus plasmid	BC000192	1719	Human	Adenovirus plasmid	GFP	3xflag (C-Terminal)	EF1	Detail
vGMLP000510	Human DHFR/DHFRP1/DYR Lentivirus particle	NM_000791	1719	Human	Lentivirus particle	ZsGreen	3xflag (C-Terminal)	CMV	Detail
vGMAP000102	Human DHFR Adenovirus particle	BC000192	1719	Human	Adenovirus particle	GFP	3xflag (C-Terminal)	EF1	Detail
pGMLPm000076	Mouse Dhfr/8430436I03Rik/AA607882 Lentivirus plasmid	NM_010049	13361	Mouse	Lentivirus plasmid	ZsGreen	3xflag (C-Terminal)	CMV	Detail
vGMLPm000076	Mouse Dhfr/8430436I03Rik/AA607882 Lentivirus particle	NM_010049	13361	Mouse	Lentivirus particle	ZsGreen	3xflag (C-Terminal)	CMV	Detail

DHFR siRNA/miRNA/oligo for RNA interfence (RNAi)

Cat No.	Product Name	GeneID	Species	Grade	Detail
pGMoligo1719	Pre-made Human DHFR/DYR/DHFR1 siRNA oligo Duplex	1719	Human	In-vitro grade; in-vivo grade	Detail
pGMoligo24312	Pre-made Rat Dhfr/Dhfr1 siRNA oligo Duplex	24312	Rat	In-vitro grade; in-vivo grade	Detail
pGMoligo13361	Pre-made Mouse Dhfr/8430436I03Rik siRNA oligo Duplex	13361	Mouse	In-vitro grade; in-vivo grade	Detail
pGMoligo711268	Pre-made Cynomolgus/Rhesus macaque DHFR siRNA oligo Duplex	711268	Cynomolgus/Rhesus macaque	In-vitro grade; in-vivo grade	Detail
pGMoligo101087964	Pre-made Cat/Feline DHFR siRNA oligo Duplex	101087964	Cat/Feline	In-vitro grade; in-vivo grade	Detail
pGMoligo479165	Pre-made Dog/Canine DHFR siRNA oligo Duplex	479165	Dog/Canine	In-vitro grade; in-vivo grade	Detail
pGMoligo508809	Pre-made Bovines/Cattle DHFR siRNA oligo Duplex	508809	Bovines/Cattle	In-vitro grade; in-vivo grade	Detail
pGMoligo100073256	Pre-made Equine/Horse DHFR siRNA oligo Duplex	100073256	Equine/Horse	In-vitro grade; in-vivo grade	Detail

DHFR antibody/GMab

Cat No.	Species	Antibody Name	Format	Classified by tag	Detail
GM-Tg-hg-T17345-Ab	Human	Anti-Human DHFR monoclonal antibody	mab	Therapeutics Target antibody	Detail
GM-Tg-rg-T17345-Ab	Rat	Anti-Rat DHFR monoclonal antibody	mab	Therapeutics Target antibody	Detail
GM-Tg-mg-T17345-Ab	Mouse	Anti-Mouse DHFR monoclonal antibody	mab	Therapeutics Target antibody	Detail
GM-Tg-cynog-T17345-Ab	Cynomolgus/Rhesus macaque	Anti-Cynomolgus/Rhesus macaque DHFR monoclonal antibody	mab	Therapeutics Target antibody	Detail
GM-Tg-felg-T17345-Ab	Cat/Feline	Anti-Cat/Feline DHFR monoclonal antibody	mab	Therapeutics Target antibody	Detail
GM-Tg-cang-T17345-Ab	Dog/Canine	Anti-Dog/Canine DHFR monoclonal antibody	mab	Therapeutics Target antibody	Detail
GM-Tg-bovg-T17345-Ab	Bovines/Cattle	Anti-Bovines/Cattle DHFR monoclonal antibody	mab	Therapeutics Target antibody	Detail
GM-Tg-equg-T17345-Ab	Equine/Horse	Anti-Equine/Horse DHFR monoclonal antibody	mab	Therapeutics Target antibody	Detail

DHFR recombinant protein

Cat No.	Species	Antigen Name	Expression Platform	Detail
GM-Tg-hg-T17345-Ag	Human	Human DHFR recombinant protein	Mammalian cell	Detail
GM-Tg-rg-T17345-Ag	Rat	Rat DHFR recombinant protein	Mammalian cell	Detail
GM-Tg-mg-T17345-Ag	Mouse	Mouse DHFR recombinant protein	Mammalian cell	Detail
GM-Tg-cynog-T17345-Ag	Cynomolgus/Rhesus macaque	Cynomolgus/Rhesus macaque DHFR recombinant protein	Mammalian cell	Detail
GM-Tg-felg-T17345-Ag	Cat/Feline	Cat/Feline DHFR recombinant protein	Mammalian cell	Detail
GM-Tg-cang-T17345-Ag	Dog/Canine	Dog/Canine DHFR recombinant protein	Mammalian cell	Detail
GM-Tg-bovg-T17345-Ag	Bovines/Cattle	Bovines/Cattle DHFR recombinant protein	Mammalian cell	Detail
GM-Tg-equg-T17345-Ag	Equine/Horse	Equine/Horse DHFR recombinant protein	Mammalian cell	Detail