Recombinant multi-species DHFR protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine DHFR protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the functional dihydrofolate reductase gene has been mapped to chromosome 5, multiple intronless processed pseudogenes or dihydrofolate reductase-like genes have been identified on separate chromosomes. Dihydrofolate reductase deficiency has been linked to megaloblastic anemia. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2014]
The Alternative Names of target: 8430436I03Rik,DHFR,DHFR1,DHFRP1,DYR,Dhfr,Dhfr1,Dihydrofolate reductase

Target products collectionGo to DHFR products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T17345-Ag-1/ GM-Tg-hg-T17345-Ag-2 Human DHFR protein Human
GM-Tg-rg-T17345-Ag-1/ GM-Tg-rg-T17345-Ag-2 Rat DHFR protein Rat
GM-Tg-mg-T17345-Ag-1/ GM-Tg-mg-T17345-Ag-2 Mouse DHFR protein Mouse
GM-Tg-cynog-T17345-Ag-1/ GM-Tg-cynog-T17345-Ag-2 Cynomolgus/Rhesus macaque DHFR protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T17345-Ag-1/ GM-Tg-felg-T17345-Ag-2 Feline DHFR protein Feline
GM-Tg-cang-T17345-Ag-1/ GM-Tg-cang-T17345-Ag-2 Canine DHFR protein Canine
GM-Tg-bovg-T17345-Ag-1/ GM-Tg-bovg-T17345-Ag-2 Bovine DHFR protein Bovine
GM-Tg-equg-T17345-Ag-1/ GM-Tg-equg-T17345-Ag-2 Equine DHFR protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T17345-Ag-1/ GM-Tg-hg-T17345-Ag-2; GM-Tg-rg-T17345-Ag-1/ GM-Tg-rg-T17345-Ag-2;
GM-Tg-mg-T17345-Ag-1/ GM-Tg-mg-T17345-Ag-2; GM-Tg-cynog-T17345-Ag-1/ GM-Tg-cynog-T17345-Ag-2;
GM-Tg-felg-T17345-Ag-1/ GM-Tg-felg-T17345-Ag-2; GM-Tg-cang-T17345-Ag-1/ GM-Tg-cang-T17345-Ag-2;
GM-Tg-bovg-T17345-Ag-1/ GM-Tg-bovg-T17345-Ag-2; GM-Tg-equg-T17345-Ag-1/ GM-Tg-equg-T17345-Ag-2
Products Name DHFR protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name DHFR
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine DHFR protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.