Explore Granzyme B/GZMB gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Secreted Protein/Potential Cytokines.
This gene encodes a member of the granzyme subfamily of proteins, part of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease, which induces target cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing. Expression of this gene may be elevated in human patients with cardiac fibrosis. [provided by RefSeq, Sep 2016]
| Target ID |
GM-T08298
|
| Target Name |
Granzyme B/GZMB
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
3002
|
| Gene ID |
14939 (Mus musculus), 3002 (Homo sapiens), 716518 (Macaca mulatta)
|
| Target Alternative Names |
Gzmb,GZMB,GZB,CCP1,Ctla1,Ctla-1,CCP-1/C11,C11,HLP,CCPI,CGL1,CSPB,SECT,CGL-1,CSP-B,CTLA1,CTSGL1
|
| Uniprot Accession |
P04187,P10144
|
| Uniprot Entry Name |
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
Apoptosis, Natural killer cell mediated cytotoxicity, Type I diabetes mellitus, Autoimmune thyroid disease, Allograft rejection, Graft-versus-host disease
|
| Gene Ensembl |
ENSMUSG00000015437, ENSG00000100453
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of Granzyme B/GZMB cDNA Clones/ORF Plasmid
Granzyme B/GZMB siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo3002 | Pre-made Human GZMB/C11/HLP siRNA oligo Duplex | 3002 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo14939 | Pre-made Mouse Gzmb/GZB/CCP1 siRNA oligo Duplex | 14939 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo716518 | Pre-made Cynomolgus/Rhesus macaque GZMB siRNA oligo Duplex | 716518 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
Granzyme B/GZMB antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T08298-Ab | Human | Anti-Human Granzyme B/GZMB monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T08298-Ab | Mouse | Anti-Mouse Granzyme B/GZMB monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T08298-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque Granzyme B/GZMB monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
Granzyme B/GZMB recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T08298-Ag | Human | Human Granzyme B/GZMB recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T08298-Ag | Mouse | Mouse Granzyme B/GZMB recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T08298-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque Granzyme B/GZMB recombinant protein | Mammalian cell | Detail |
