Recombinant multi-species Granzyme B/GZMB protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine Granzyme B/GZMB protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a member of the granzyme subfamily of proteins, part of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease, which induces target cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing. Expression of this gene may be elevated in human patients with cardiac fibrosis. [provided by RefSeq, Sep 2016]
The Alternative Names of target: C11,CCP-1/C11,CCP1,CCPI,CGL-1,CGL1,CSP-B,CSPB,CTLA-1,CTLA1,CTSGL1,Cathepsin G-like 1 (CTSGL1),Ctla-1,Ctla1,Cytotoxic T-lymphocyte proteinase 2 (Lymphocyte protease),Fragmentin-2,GZB,GZMB,Granzyme B,Granzyme-2,Gzmb,HLP,Human lymphocyte protein (HLP),SECT,T-cell serine protease 1-3E

Target products collectionGo to Granzyme B/GZMB products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T08298-Ag-1/ GM-Tg-hg-T08298-Ag-2 Human Granzyme B/GZMB protein Human
GM-Tg-rg-T08298-Ag-1/ GM-Tg-rg-T08298-Ag-2 Rat Granzyme B/GZMB protein Rat
GM-Tg-mg-T08298-Ag-1/ GM-Tg-mg-T08298-Ag-2 Mouse Granzyme B/GZMB protein Mouse
GM-Tg-cynog-T08298-Ag-1/ GM-Tg-cynog-T08298-Ag-2 Cynomolgus/Rhesus macaque Granzyme B/GZMB protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T08298-Ag-1/ GM-Tg-felg-T08298-Ag-2 Feline Granzyme B/GZMB protein Feline
GM-Tg-cang-T08298-Ag-1/ GM-Tg-cang-T08298-Ag-2 Canine Granzyme B/GZMB protein Canine
GM-Tg-bovg-T08298-Ag-1/ GM-Tg-bovg-T08298-Ag-2 Bovine Granzyme B/GZMB protein Bovine
GM-Tg-equg-T08298-Ag-1/ GM-Tg-equg-T08298-Ag-2 Equine Granzyme B/GZMB protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T08298-Ag-1/ GM-Tg-hg-T08298-Ag-2; GM-Tg-rg-T08298-Ag-1/ GM-Tg-rg-T08298-Ag-2;
GM-Tg-mg-T08298-Ag-1/ GM-Tg-mg-T08298-Ag-2; GM-Tg-cynog-T08298-Ag-1/ GM-Tg-cynog-T08298-Ag-2;
GM-Tg-felg-T08298-Ag-1/ GM-Tg-felg-T08298-Ag-2; GM-Tg-cang-T08298-Ag-1/ GM-Tg-cang-T08298-Ag-2;
GM-Tg-bovg-T08298-Ag-1/ GM-Tg-bovg-T08298-Ag-2; GM-Tg-equg-T08298-Ag-1/ GM-Tg-equg-T08298-Ag-2
Products Name Granzyme B/GZMB protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name Granzyme B/GZMB
Protein Sub-location Secreted Protein/Potential Cytokines
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine Granzyme B/GZMB protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.