Explore MASP2 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Secreted Protein/Potential Cytokines.
This gene encodes a member of the peptidase S1 family of serine proteases. The encoded preproprotein is proteolytically processed to generate A and B chains that heterodimerize to form the mature protease. This protease cleaves complement components C2 and C4 in order to generate C3 convertase in the lectin pathway of the complement system. The encoded protease also plays a role in the coagulation cascade through cleavage of prothrombin to form thrombin. Myocardial infarction and acute stroke patients exhibit reduced serum concentrations of the encoded protein. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
| Target ID |
GM-T07448
|
| Target Name |
MASP2
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
10747
|
| Gene ID |
100056770 (Equus caballus), 101099568 (Felis catus), 10747 (Homo sapiens), 17175 (Mus musculus)
487447 (Canis lupus familiaris), 505819 (Bos taurus), 64459 (Rattus norvegicus), 722714 (Macaca mulatta)
|
| Target Alternative Names |
MAP-2,MAP19,MASP-2,MASP1P1,MASP2,MAp19,MBL-associated serine protease 2,Mannan-binding lectin serine protease 2,Mannose-binding protein-associated serine protease 2 (MASP-2),Masp2,sMAP
|
| Uniprot Accession |
O00187,Q91WP0,Q9JJS8
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Category |
Therapeutics Target, INN Index
|
| Disease |
Acute appendicitis, Dent disease, Contrast - Induced Nephropathy, Congenital occlusion of ureteropelvic junction, Type 2 diabetes mellitus with diabetic nephropathy
|
| Disease from KEGG |
Complement and coagulation cascades, Staphylococcus aureus infection
|
| Gene Ensembl |
ENSECAG00000021756, ENSG00000009724, ENSMUSG00000028979, ENSCAFG00845003035, ENSBTAG00000012808, ENSMMUG00000007459
|
Pre-made viral vector of MASP2 cDNA Clones/ORF Plasmid
MASP2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo10747 | Pre-made Human MASP2/sMAP/MAP-2 siRNA oligo Duplex | 10747 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo64459 | Pre-made Rat Masp2/MAp19/MASP-2 siRNA oligo Duplex | 64459 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo17175 | Pre-made Mouse Masp2/MAp19/MASP-2 siRNA oligo Duplex | 17175 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo722714 | Pre-made Cynomolgus/Rhesus macaque MASP2 siRNA oligo Duplex | 722714 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101099568 | Pre-made Cat/Feline MASP2 siRNA oligo Duplex | 101099568 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo487447 | Pre-made Dog/Canine MASP2 siRNA oligo Duplex | 487447 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo505819 | Pre-made Bovines/Cattle MASP2 siRNA oligo Duplex | 505819 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100056770 | Pre-made Equine/Horse MASP2 siRNA oligo Duplex | 100056770 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
MASP2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T07448-Ab | Human | Anti-Human MASP2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T07448-Ab | Rat | Anti-Rat MASP2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T07448-Ab | Mouse | Anti-Mouse MASP2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T07448-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque MASP2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T07448-Ab | Cat/Feline | Anti-Cat/Feline MASP2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T07448-Ab | Dog/Canine | Anti-Dog/Canine MASP2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T07448-Ab | Bovines/Cattle | Anti-Bovines/Cattle MASP2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T07448-Ab | Equine/Horse | Anti-Equine/Horse MASP2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
MASP2 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T07448-Ag | Human | Human MASP2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T07448-Ag | Rat | Rat MASP2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T07448-Ag | Mouse | Mouse MASP2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T07448-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque MASP2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T07448-Ag | Cat/Feline | Cat/Feline MASP2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T07448-Ag | Dog/Canine | Dog/Canine MASP2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T07448-Ag | Bovines/Cattle | Bovines/Cattle MASP2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T07448-Ag | Equine/Horse | Equine/Horse MASP2 recombinant protein | Mammalian cell | Detail |
