Explore IFN beta/IFN beta1/IFNB1 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Secreted Protein/Potential Cytokines.
This gene encodes a cytokine that belongs to the interferon family of signaling proteins, which are released as part of the innate immune response to pathogens. The protein encoded by this gene belongs to the type I class of interferons, which are important for defense against viral infections. In addition, type I interferons are involved in cell differentiation and anti-tumor defenses. Following secretion in response to a pathogen, type I interferons bind a homologous receptor complex and induce transcription of genes such as those encoding inflammatory cytokines and chemokines. Overactivation of type I interferon secretion is linked to autoimmune diseases. Mice deficient for this gene display several phenotypes including defects in B cell maturation and increased susceptibility to viral infection. [provided by RefSeq, Sep 2015]
| Target ID |
GM-T02808
|
| Target Name |
IFN beta/IFN beta1/IFNB1
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
3456
|
| Gene ID |
100052545 (Equus caballus), 15977 (Mus musculus), 24481 (Rattus norvegicus), 3456 (Homo sapiens)
481558 (Canis lupus familiaris), 493849 (Felis catus), 711414 (Macaca mulatta)
|
| Target Alternative Names |
Fibroblast interferon,IF1DA1,IFB,IFF,IFN beta,IFN beta1,IFN-beta,IFNB,IFNB1,If1da1,Ifb,Ifnb,Ifnb1,Interferon beta
|
| Uniprot Accession |
P05012,P01575,P70499,P01574,Q9N2J0
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Category |
Therapeutics Target, Immuno-oncology Target, Cytokine Target
|
| Disease from KEGG |
Cytokine-cytokine receptor interaction, PI3K-Akt signaling pathway, Osteoclast differentiation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, RIG-I-like receptor signaling pathway, JAK-STAT signaling pathway, Natural killer cell mediated cytotoxicity, TNF signaling pathway, Alcoholic liver disease, Yersinia infection, Chagas disease, Tuberculosis, Hepatitis C, Hepatitis B, Measles, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Epstein-Barr virus infection, Lipid and atherosclerosis
|
| Gene Ensembl |
ENSMUSG00000048806, ENSG00000171855, ENSCAFG00845016293, ENSMMUG00000019067
|
| Target Classification |
Checkpoint-Immuno Oncology
|
Pre-made viral vector of IFN beta/IFN beta1/IFNB1 cDNA Clones/ORF Plasmid
IFN beta/IFN beta1/IFNB1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo3456 | Pre-made Human IFNB1/IFB/IFF siRNA oligo Duplex | 3456 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo24481 | Pre-made Rat Ifnb1/Ifnb/If1da1 siRNA oligo Duplex | 24481 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo15977 | Pre-made Mouse Ifnb1/Ifb/IFNB siRNA oligo Duplex | 15977 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo711414 | Pre-made Cynomolgus/Rhesus macaque IFNB1 siRNA oligo Duplex | 711414 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo493849 | Pre-made Cat/Feline IFNB1/IFNB siRNA oligo Duplex | 493849 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo481558 | Pre-made Dog/Canine IFNB1 siRNA oligo Duplex | 481558 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100052545 | Pre-made Equine/Horse IFNB1/IFNB/IF1DA1 siRNA oligo Duplex | 100052545 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
IFN beta/IFN beta1/IFNB1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T02808-Ab | Human | Anti-Human IFN beta/IFN beta1/IFNB1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-rg-T02808-Ab | Rat | Anti-Rat IFN beta/IFN beta1/IFNB1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-mg-T02808-Ab | Mouse | Anti-Mouse IFN beta/IFN beta1/IFNB1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cynog-T02808-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque IFN beta/IFN beta1/IFNB1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-felg-T02808-Ab | Cat/Feline | Anti-Cat/Feline IFN beta/IFN beta1/IFNB1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cang-T02808-Ab | Dog/Canine | Anti-Dog/Canine IFN beta/IFN beta1/IFNB1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-equg-T02808-Ab | Equine/Horse | Anti-Equine/Horse IFN beta/IFN beta1/IFNB1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
IFN beta/IFN beta1/IFNB1 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T02808-Ag | Human | Human IFN beta/IFN beta1/IFNB1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T02808-Ag | Rat | Rat IFN beta/IFN beta1/IFNB1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T02808-Ag | Mouse | Mouse IFN beta/IFN beta1/IFNB1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T02808-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque IFN beta/IFN beta1/IFNB1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T02808-Ag | Cat/Feline | Cat/Feline IFN beta/IFN beta1/IFNB1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T02808-Ag | Dog/Canine | Dog/Canine IFN beta/IFN beta1/IFNB1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T02808-Ag | Equine/Horse | Equine/Horse IFN beta/IFN beta1/IFNB1 recombinant protein | Mammalian cell | Detail |
