Explore RUNX2 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Introcelluar Protein.
This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Two regions of potential trinucleotide repeat expansions are present in the N-terminal region of the encoded protein, and these and other mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing. [provided by RefSeq, Jul 2016]
| Target ID |
GM-T02259
|
| Target Name |
RUNX2
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
860
|
| Gene ID |
100033890 (Equus caballus), 101089612 (Felis catus), 12393 (Mus musculus), 367218 (Rattus norvegicus) 449531 (Canis lupus familiaris), 536911 (Bos taurus), 703331 (Macaca mulatta), 860 (Homo sapiens)
|
| Target Alternative Names |
AML3,Acute myeloid leukemia 3 protein,CBF-alpha-1,CBFA1,CCD,CCD1,CLCD,Cbf,Cbfa-1,Cbfa1,Core-binding factor subunit alpha-1 (CBF-alpha-1),LS3,OSF-2,OSF2,Oncogene AML-3,Osf2,Osteoblast-specific transcription factor 2 (OSF-2),PEA2aA,PEBP2-alpha A),PEBP2aA,Pebp2a1,Pebpa2a,Polyomavirus enhancer-binding protein 2 alpha A subunit (PEA2-alpha A,RUNX2,Runt-related transcription factor 2,Runx2,SL3-3 enhancer factor 1 alpha A subunit,SL3/AKV core-binding factor alpha A subunit
|
| Uniprot Accession |
Q9XSB7,Q08775,Q9Z2J9,Q13950
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
Parathyroid hormone synthesis, secretion and action
|
| Gene Ensembl |
ENSECAG00000020875, ENSMUSG00000039153, ENSCAFG00845012369, ENSBTAG00000004104, ENSMMUG00000019819, ENSG00000124813
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of RUNX2 cDNA Clones/ORF Plasmid
RUNX2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo860 | Pre-made Human RUNX2/CCD/AML3 siRNA oligo Duplex | 860 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo367218 | Pre-made Rat Runx2/Cbfa1/OSF-2 siRNA oligo Duplex | 367218 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo12393 | Pre-made Mouse Runx2/Cbf/LS3 siRNA oligo Duplex | 12393 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo703331 | Pre-made Cynomolgus/Rhesus macaque RUNX2 siRNA oligo Duplex | 703331 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101089612 | Pre-made Cat/Feline RUNX2 siRNA oligo Duplex | 101089612 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo449531 | Pre-made Dog/Canine RUNX2 siRNA oligo Duplex | 449531 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo536911 | Pre-made Bovines/Cattle RUNX2 siRNA oligo Duplex | 536911 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100033890 | Pre-made Equine/Horse RUNX2 siRNA oligo Duplex | 100033890 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
RUNX2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T02259-Ab | Human | Anti-Human RUNX2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T02259-Ab | Rat | Anti-Rat RUNX2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T02259-Ab | Mouse | Anti-Mouse RUNX2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T02259-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque RUNX2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T02259-Ab | Cat/Feline | Anti-Cat/Feline RUNX2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T02259-Ab | Dog/Canine | Anti-Dog/Canine RUNX2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T02259-Ab | Bovines/Cattle | Anti-Bovines/Cattle RUNX2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T02259-Ab | Equine/Horse | Anti-Equine/Horse RUNX2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
RUNX2 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T02259-Ag | Human | Human RUNX2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T02259-Ag | Rat | Rat RUNX2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T02259-Ag | Mouse | Mouse RUNX2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T02259-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque RUNX2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T02259-Ag | Cat/Feline | Cat/Feline RUNX2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T02259-Ag | Dog/Canine | Dog/Canine RUNX2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T02259-Ag | Bovines/Cattle | Bovines/Cattle RUNX2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T02259-Ag | Equine/Horse | Equine/Horse RUNX2 recombinant protein | Mammalian cell | Detail |