Recombinant multi-species RUNX2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine RUNX2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Two regions of potential trinucleotide repeat expansions are present in the N-terminal region of the encoded protein, and these and other mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing. [provided by RefSeq, Jul 2016]
The Alternative Names of target: AML3,Acute myeloid leukemia 3 protein,CBF-alpha-1,CBFA1,CCD,CCD1,CLCD,Cbf,Cbfa-1,Cbfa1,Core-binding factor subunit alpha-1 (CBF-alpha-1),LS3,OSF-2,OSF2,Oncogene AML-3,Osf2,Osteoblast-specific transcription factor 2 (OSF-2),PEA2aA,PEBP2-alpha A),PEBP2aA,Pebp2a1,Pebpa2a,Polyomavirus enhancer-binding protein 2 alpha A subunit (PEA2-alpha A,RUNX2,Runt-related transcription factor 2,Runx2,SL3-3 enhancer factor 1 alpha A subunit,SL3/AKV core-binding factor alpha A subunit

Target products collectionGo to RUNX2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T02259-Ag-1/ GM-Tg-hg-T02259-Ag-2 Human RUNX2 protein Human
GM-Tg-rg-T02259-Ag-1/ GM-Tg-rg-T02259-Ag-2 Rat RUNX2 protein Rat
GM-Tg-mg-T02259-Ag-1/ GM-Tg-mg-T02259-Ag-2 Mouse RUNX2 protein Mouse
GM-Tg-cynog-T02259-Ag-1/ GM-Tg-cynog-T02259-Ag-2 Cynomolgus/Rhesus macaque RUNX2 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T02259-Ag-1/ GM-Tg-felg-T02259-Ag-2 Feline RUNX2 protein Feline
GM-Tg-cang-T02259-Ag-1/ GM-Tg-cang-T02259-Ag-2 Canine RUNX2 protein Canine
GM-Tg-bovg-T02259-Ag-1/ GM-Tg-bovg-T02259-Ag-2 Bovine RUNX2 protein Bovine
GM-Tg-equg-T02259-Ag-1/ GM-Tg-equg-T02259-Ag-2 Equine RUNX2 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T02259-Ag-1/ GM-Tg-hg-T02259-Ag-2; GM-Tg-rg-T02259-Ag-1/ GM-Tg-rg-T02259-Ag-2;
GM-Tg-mg-T02259-Ag-1/ GM-Tg-mg-T02259-Ag-2; GM-Tg-cynog-T02259-Ag-1/ GM-Tg-cynog-T02259-Ag-2;
GM-Tg-felg-T02259-Ag-1/ GM-Tg-felg-T02259-Ag-2; GM-Tg-cang-T02259-Ag-1/ GM-Tg-cang-T02259-Ag-2;
GM-Tg-bovg-T02259-Ag-1/ GM-Tg-bovg-T02259-Ag-2; GM-Tg-equg-T02259-Ag-1/ GM-Tg-equg-T02259-Ag-2
Products Name RUNX2 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name RUNX2
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine RUNX2 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.