MDM2/HDM2 Target & Gene Products-cDNA ORF clones/siRNA/antibody/protein

Explore MDM2/HDM2 gene products and cross-species research data at TarMart platform. Discover comprehensive biological information, expression tools, and therapeutic insights for Homo sapiens (human), Cynomolgus monkeys, rodents (mouse/rat), canines, felines, bovines, and equines. Your premier destination for multi-species gene research solutions
Target sublocation: Introcelluar Protein.
This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013]

Target ID GM-T00176
Target Name MDM2/HDM2
Gene Group ldentifer
（Target Gene ID in Homo species) 		4193
Gene ID 100052084 (Equus caballus), 17246 (Mus musculus), 314856 (Rattus norvegicus), 403693 (Canis lupus familiaris)
4193 (Homo sapiens), 493939 (Felis catus), 540378 (Bos taurus), 718284 (Macaca mulatta)
Target Alternative Names 1700007J15Rik,ACTFS,Double minute 2 protein (Hdm2),E3 ubiquitin-protein ligase Mdm2,HDM2,HDMX,LSKB,MDM2,Mdm-2,Mdm2,Oncoprotein Mdm2,RING-type E3 ubiquitin transferase Mdm2,edm2,hdm2,p53-binding protein Mdm2
Uniprot Accession P56951,P23804,P56950,Q00987,Q7YRZ8
Protein Sub-location Introcelluar Protein
Category Therapeutics Target
Disease cancer, Breast Cancer
Disease from KEGG Endocrine resistance, FoxO signaling pathway, p53 signaling pathway, PI3K-Akt signaling pathway, Cellular senescence, C-type lectin receptor signaling pathway, Thyroid hormone signaling pathway, Human cytomegalovirus infection, Human papillomavirus infection, Epstein-Barr virus infection, Pathways in cancer, Proteoglycans in cancer, Glioma, Prostate cancer, Melanoma, Bladder cancer, Chronic myeloid leukemia
Gene Ensembl ENSECAG00000013604, ENSMUSG00000020184, ENSCAFG00845016387, ENSG00000135679, ENSBTAG00000010422, ENSMMUG00000055447


Pre-made viral vector of MDM2/HDM2 cDNA Clones/ORF Plasmid

Cat No.Product NameNMIDGeneIDSpeciesTypeMarkerFusion TagPromoterDetail
pGMLP005735Human MDM2/ACTFS/hdm2 Lentivirus plasmidNM_002392.54193HumanLentivirus plasmidZsGreen3xflag (C-Terminal)CMVDetail
pGMPC001312Human MDM2/ACTFS/hdm2 Mammalian (Non-Viral Vector) plasmidNM_002392.54193HumanMammalian (Non-Viral Vector) plasmidEGFP3xflag (C-Terminal)CMVDetail
vGMAP-SPh-141Human MDM2/ACTFS/hdm2 Adenovirus particleNM_0023924193HumanAdenovirus particleEGFP3xflag (C-Terminal)EF1Detail
vGMLP-SPh-001Human MDM2/ACTFS/hdm2 Lentivirus particleNM_0023924193HumanLentivirus particleZsGreen3xflag (C-Terminal)CMVDetail
vGMLV000680Human MDM2/ACTFS/hdm2 Lentivirus particleNM_002392.54193HumanLentivirus particleZsGreen3xflag (C-Terminal)CMVDetail
vGMLP005735Human MDM2/ACTFS/hdm2 Lentivirus particleNM_002392.54193HumanLentivirus particleZsGreen3xflag (C-Terminal)CMVDetail
pGMPC004926Human MDM2/ACTFS/hdm2 Mammalian (Non-Viral Vector) plasmidNM_001367990.14193HumanMammalian (Non-Viral Vector) plasmidZsGreen3xflag (C-Terminal)CMVDetail
pGMPC004828Human MDM2/ACTFS/hdm2 Mammalian (Non-Viral Vector) plasmidNM_002392.54193HumanMammalian (Non-Viral Vector) plasmidNull6xHis (C-Terminal)CMVDetail
pGMPC004812Human MDM2/ACTFS/hdm2 Mammalian (Non-Viral Vector) plasmidNM_002392.64193HumanMammalian (Non-Viral Vector) plasmidEGFPMYC (C-Terminal)EF1Detail
pGMLP-SPh-001Human MDM2/ACTFS/hdm2 Lentivirus plasmidNM_0023924193HumanLentivirus plasmidZsGreen3xflag (C-Terminal)CMVDetail
pGMAP-SPh-141Human MDM2/ACTFS/hdm2 Adenovirus plasmidNM_0023924193HumanAdenovirus plasmidEGFP3xflag (C-Terminal)EF1Detail
pGMLV000680Human MDM2/ACTFS/hdm2 Lentivirus plasmidNM_002392.54193HumanLentivirus plasmidZsGreen3xflag (C-Terminal)CMVDetail
pGMLV000678Rat Mdm2 Lentivirus plasmidNM_001108099.1314856RatLentivirus plasmidNullNullCMVDetail
vGMLV000678Rat Mdm2 Lentivirus particleNM_001108099.1314856RatLentivirus particleNullNullCMVDetail
pGMPC000174Mouse Mdm2/1700007J15Rik/AA415488 Mammalian (Non-Viral Vector) plasmidNM_010786.417246MouseMammalian (Non-Viral Vector) plasmidEGFP3xflag (C-Terminal)EF1Detail
pGMAP-SPm-128Mouse Mdm2/1700007J15Rik/AA415488 Adenovirus plasmidNM_01078617246MouseAdenovirus plasmidEGFP3xflag (C-Terminal)EF1Detail
pGMLP-SPm-001Mouse Mdm2/1700007J15Rik/AA415488 Lentivirus plasmidNM_01078617246MouseLentivirus plasmidZsGreen3xflag (C-Terminal)CMVDetail
vGMAD000668Mouse Mdm2/1700007J15Rik/AA415488 Adenovirus particleNM_01078617246MouseAdenovirus particleEGFP3xflag (C-Terminal)EF1Detail
pGMAD000668Mouse Mdm2/1700007J15Rik/AA415488 Adenovirus plasmidNM_01078617246MouseAdenovirus plasmidEGFP3xflag (C-Terminal)EF1Detail
vGMLP-SPm-001Mouse Mdm2/1700007J15Rik/AA415488 Lentivirus particleNM_01078617246MouseLentivirus particleZsGreen3xflag (C-Terminal)CMVDetail
vGMAP-SPm-128Mouse Mdm2/1700007J15Rik/AA415488 Adenovirus particleNM_01078617246MouseAdenovirus particleEGFP3xflag (C-Terminal)EF1Detail


MDM2/HDM2 siRNA/miRNA/oligo for RNA interfence (RNAi)

Cat No.Product NameGeneIDSpeciesGradeDetail
pGMoligo4193Pre-made Human MDM2/HDMX/LSKB siRNA oligo Duplex4193HumanIn-vitro grade; in-vivo gradeDetail
pGMoligo314856Pre-made Rat Mdm2 siRNA oligo Duplex314856RatIn-vitro grade; in-vivo gradeDetail
pGMoligo17246Pre-made Mouse Mdm2/Mdm-2/1700007J15Rik siRNA oligo Duplex17246MouseIn-vitro grade; in-vivo gradeDetail
pGMoligo718284Pre-made Cynomolgus/Rhesus macaque MDM2 siRNA oligo Duplex718284Cynomolgus/Rhesus macaqueIn-vitro grade; in-vivo gradeDetail
pGMoligo493939Pre-made Cat/Feline MDM2 siRNA oligo Duplex493939Cat/FelineIn-vitro grade; in-vivo gradeDetail
pGMoligo403693Pre-made Dog/Canine MDM2 siRNA oligo Duplex403693Dog/CanineIn-vitro grade; in-vivo gradeDetail
pGMoligo540378Pre-made Bovines/Cattle MDM2 siRNA oligo Duplex540378Bovines/CattleIn-vitro grade; in-vivo gradeDetail
pGMoligo100052084Pre-made Equine/Horse MDM2/edm2 siRNA oligo Duplex100052084Equine/HorseIn-vitro grade; in-vivo gradeDetail


MDM2/HDM2 antibody/GMab

Cat No.SpeciesAntibody NameFormatClassified by tagDetail
GM-Tg-hg-T00176-AbHumanAnti-Human MDM2/HDM2 monoclonal antibodymabTherapeutics Target antibodyDetail
GM-Tg-rg-T00176-AbRatAnti-Rat MDM2/HDM2 monoclonal antibodymabTherapeutics Target antibodyDetail
GM-Tg-mg-T00176-AbMouseAnti-Mouse MDM2/HDM2 monoclonal antibodymabTherapeutics Target antibodyDetail
GM-Tg-cynog-T00176-AbCynomolgus/Rhesus macaqueAnti-Cynomolgus/Rhesus macaque MDM2/HDM2 monoclonal antibodymabTherapeutics Target antibodyDetail
GM-Tg-felg-T00176-AbCat/FelineAnti-Cat/Feline MDM2/HDM2 monoclonal antibodymabTherapeutics Target antibodyDetail
GM-Tg-cang-T00176-AbDog/CanineAnti-Dog/Canine MDM2/HDM2 monoclonal antibodymabTherapeutics Target antibodyDetail
GM-Tg-bovg-T00176-AbBovines/CattleAnti-Bovines/Cattle MDM2/HDM2 monoclonal antibodymabTherapeutics Target antibodyDetail
GM-Tg-equg-T00176-AbEquine/HorseAnti-Equine/Horse MDM2/HDM2 monoclonal antibodymabTherapeutics Target antibodyDetail


MDM2/HDM2 recombinant protein

Cat No.SpeciesAntigen NameExpression PlatformDetail
GM-Tg-hg-T00176-AgHumanHuman MDM2/HDM2 recombinant proteinMammalian cellDetail
GM-Tg-rg-T00176-AgRatRat MDM2/HDM2 recombinant proteinMammalian cellDetail
GM-Tg-mg-T00176-AgMouseMouse MDM2/HDM2 recombinant proteinMammalian cellDetail
GM-Tg-cynog-T00176-AgCynomolgus/Rhesus macaqueCynomolgus/Rhesus macaque MDM2/HDM2 recombinant proteinMammalian cellDetail
GM-Tg-felg-T00176-AgCat/FelineCat/Feline MDM2/HDM2 recombinant proteinMammalian cellDetail
GM-Tg-cang-T00176-AgDog/CanineDog/Canine MDM2/HDM2 recombinant proteinMammalian cellDetail
GM-Tg-bovg-T00176-AgBovines/CattleBovines/Cattle MDM2/HDM2 recombinant proteinMammalian cellDetail
GM-Tg-equg-T00176-AgEquine/HorseEquine/Horse MDM2/HDM2 recombinant proteinMammalian cellDetail