Recombinant multi-species MDM2/HDM2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine MDM2/HDM2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013]
The Alternative Names of target: 1700007J15Rik,ACTFS,Double minute 2 protein (Hdm2),E3 ubiquitin-protein ligase Mdm2,HDM2,HDMX,LSKB,MDM2,Mdm-2,Mdm2,Oncoprotein Mdm2,RING-type E3 ubiquitin transferase Mdm2,edm2,hdm2,p53-binding protein Mdm2

Target products collectionGo to MDM2/HDM2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T00176-Ag-1/ GM-Tg-hg-T00176-Ag-2 Human MDM2/HDM2 protein Human
GM-Tg-rg-T00176-Ag-1/ GM-Tg-rg-T00176-Ag-2 Rat MDM2/HDM2 protein Rat
GM-Tg-mg-T00176-Ag-1/ GM-Tg-mg-T00176-Ag-2 Mouse MDM2/HDM2 protein Mouse
GM-Tg-cynog-T00176-Ag-1/ GM-Tg-cynog-T00176-Ag-2 Cynomolgus/Rhesus macaque MDM2/HDM2 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T00176-Ag-1/ GM-Tg-felg-T00176-Ag-2 Feline MDM2/HDM2 protein Feline
GM-Tg-cang-T00176-Ag-1/ GM-Tg-cang-T00176-Ag-2 Canine MDM2/HDM2 protein Canine
GM-Tg-bovg-T00176-Ag-1/ GM-Tg-bovg-T00176-Ag-2 Bovine MDM2/HDM2 protein Bovine
GM-Tg-equg-T00176-Ag-1/ GM-Tg-equg-T00176-Ag-2 Equine MDM2/HDM2 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T00176-Ag-1/ GM-Tg-hg-T00176-Ag-2; GM-Tg-rg-T00176-Ag-1/ GM-Tg-rg-T00176-Ag-2;
GM-Tg-mg-T00176-Ag-1/ GM-Tg-mg-T00176-Ag-2; GM-Tg-cynog-T00176-Ag-1/ GM-Tg-cynog-T00176-Ag-2;
GM-Tg-felg-T00176-Ag-1/ GM-Tg-felg-T00176-Ag-2; GM-Tg-cang-T00176-Ag-1/ GM-Tg-cang-T00176-Ag-2;
GM-Tg-bovg-T00176-Ag-1/ GM-Tg-bovg-T00176-Ag-2; GM-Tg-equg-T00176-Ag-1/ GM-Tg-equg-T00176-Ag-2
Products Name MDM2/HDM2 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name MDM2/HDM2
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine MDM2/HDM2 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
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