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Target
sublocation: Secreted Protein/Potential Cytokines.
This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq, Jul 2008]
| Target ID |
GM-SE1338
|
| Target Name |
TIMP2
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
7077
|
| Gene ID |
100034134 (Equus caballus), 101083125 (Felis catus), 21858 (Mus musculus), 282093 (Bos taurus) 29543 (Rattus norvegicus), 403633 (Canis lupus familiaris), 574357 (Macaca mulatta), 7077 (Homo sapiens)
|
| Target Alternative Names |
CSC-21K,D11Bwg1104e,DDC8,Metalloproteinase inhibitor 2,TIMP-2,TIMP2,Timp-2,Timp2,Tissue inhibitor of metalloproteinases 2 (TIMP-2)
|
| Uniprot Accession |
O77717,P25785,P16368,P30121,Q9TTY1,P16035
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Disease |
cancer, Acute kidney failure, Dent disease, Malignant neoplasm of bladder
|
| Gene Ensembl |
ENSECAG00000060149, ENSMUSG00000017466, ENSBTAG00000010899, ENSG00000035862
|
Pre-made viral vector of TIMP2 cDNA Clones/ORF Plasmid
TIMP2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo7077 | Pre-made Human TIMP2/DDC8/CSC-21K siRNA oligo Duplex | 7077 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo29543 | Pre-made Rat Timp2 siRNA oligo Duplex | 29543 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo21858 | Pre-made Mouse Timp2/Timp-2/D11Bwg1104e siRNA oligo Duplex | 21858 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo574357 | Pre-made Cynomolgus/Rhesus macaque TIMP2/TIMP-2 siRNA oligo Duplex | 574357 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101083125 | Pre-made Cat/Feline TIMP2 siRNA oligo Duplex | 101083125 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo403633 | Pre-made Dog/Canine TIMP2 siRNA oligo Duplex | 403633 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo282093 | Pre-made Bovines/Cattle TIMP2 siRNA oligo Duplex | 282093 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100034134 | Pre-made Equine/Horse TIMP2/TIMP-2 siRNA oligo Duplex | 100034134 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
TIMP2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-SE1338-Ab | Human | Anti-Human TIMP2 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-rg-SE1338-Ab | Rat | Anti-Rat TIMP2 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-mg-SE1338-Ab | Mouse | Anti-Mouse TIMP2 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cynog-SE1338-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque TIMP2 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-felg-SE1338-Ab | Cat/Feline | Anti-Cat/Feline TIMP2 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cang-SE1338-Ab | Dog/Canine | Anti-Dog/Canine TIMP2 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-bovg-SE1338-Ab | Bovines/Cattle | Anti-Bovines/Cattle TIMP2 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-equg-SE1338-Ab | Equine/Horse | Anti-Equine/Horse TIMP2 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
TIMP2 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-SE1338-Ag | Human | Human TIMP2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-SE1338-Ag | Rat | Rat TIMP2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-SE1338-Ag | Mouse | Mouse TIMP2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-SE1338-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque TIMP2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-SE1338-Ag | Cat/Feline | Cat/Feline TIMP2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-SE1338-Ag | Dog/Canine | Dog/Canine TIMP2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-SE1338-Ag | Bovines/Cattle | Bovines/Cattle TIMP2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-SE1338-Ag | Equine/Horse | Equine/Horse TIMP2 recombinant protein | Mammalian cell | Detail |