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Target
sublocation: Secreted Protein/Potential Cytokines.
This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2015]
| Target ID |
GM-SE1211
|
| Target Name |
PRSS2
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
5645
|
| Gene ID |
100686744 (Canis lupus familiaris), 101085707 (Felis catus), 111773305 (Equus caballus), 282603 (Bos taurus) 5645 (Homo sapiens), 698352 (Macaca mulatta)
|
| Target Alternative Names |
Anionic trypsinogen,PRSS2,Serine protease 2,TRY2,TRY8,TRYP2,TRYP8,Trypsin II,Trypsin-2,try10
|
| Uniprot Accession |
P06872,Q29463,P07478
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Disease |
Pancreatitis, Acute pancreatitis
|
| Disease from KEGG |
Neuroactive ligand-receptor interaction, Pancreatic secretion, Protein digestion and absorption, Influenza A
|
| Gene Ensembl |
ENSCAFG00845018895, ENSECAG00000015872, ENSG00000275896, ENSMMUG00000051032
|
Pre-made viral vector of PRSS2 cDNA Clones/ORF Plasmid
PRSS2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo5645 | Pre-made Human PRSS2/TRY2/TRY8 siRNA oligo Duplex | 5645 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo698352 | Pre-made Cynomolgus/Rhesus macaque PRSS2/try10 siRNA oligo Duplex | 698352 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101085707 | Pre-made Cat/Feline PRSS2 siRNA oligo Duplex | 101085707 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100686744 | Pre-made Dog/Canine PRSS2 siRNA oligo Duplex | 100686744 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo282603 | Pre-made Bovines/Cattle PRSS2/TRYP8 siRNA oligo Duplex | 282603 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo111773305 | Pre-made Equine/Horse PRSS2 siRNA oligo Duplex | 111773305 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
PRSS2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-SE1211-Ab | Human | Anti-Human PRSS2 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cynog-SE1211-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque PRSS2 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-felg-SE1211-Ab | Cat/Feline | Anti-Cat/Feline PRSS2 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cang-SE1211-Ab | Dog/Canine | Anti-Dog/Canine PRSS2 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-bovg-SE1211-Ab | Bovines/Cattle | Anti-Bovines/Cattle PRSS2 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-equg-SE1211-Ab | Equine/Horse | Anti-Equine/Horse PRSS2 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
PRSS2 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-SE1211-Ag | Human | Human PRSS2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-SE1211-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque PRSS2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-SE1211-Ag | Cat/Feline | Cat/Feline PRSS2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-SE1211-Ag | Dog/Canine | Dog/Canine PRSS2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-SE1211-Ag | Bovines/Cattle | Bovines/Cattle PRSS2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-SE1211-Ag | Equine/Horse | Equine/Horse PRSS2 recombinant protein | Mammalian cell | Detail |