Explore C-Reactive Protein/CRP gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Secreted Protein/Potential Cytokines.
The protein encoded by this gene belongs to the pentraxin family which also includes serum amyloid P component protein and pentraxin 3. Pentraxins are involved in complement activation and amplification via communication with complement initiation pattern recognition molecules, but also complement regulation via recruitment of complement regulators. The encoded protein has a calcium dependent ligand binding domain with a distinctive flattened beta-jellyroll structure. It exists in two forms as either a pentamer in circulation or as a nonsoluble monomer in tissues. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. Elevated expression of the encoded protein is associated with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. [provided by RefSeq, Aug 2020]
| Target ID |
GM-SE0824
|
| Target Name |
C-Reactive Protein/CRP
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
1401
|
| Gene ID |
101093079 (Felis catus), 12944 (Mus musculus), 138915014 (Equus caballus), 1401 (Homo sapiens) 25419 (Rattus norvegicus), 488629 (Canis lupus familiaris), 527553 (Bos taurus), 719454 (Macaca mulatta)
|
| Target Alternative Names |
Aa1249,Ab1-341,Ab2-196,Ac1-114,Ac1262,Ac2-069,Ba2-693,C-Reactive Protein,C-reactive protein,CRP,Crp,PTX1
|
| Uniprot Accession |
P14847,P02741,P48199
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Category |
Diagnostics Biomarker, Cytokine Target
|
| Disease |
cancer, Breast Cancer, cardiovascular disease, Pregnant state, pancreatic, renal, gastrointestinal, tissue damage, Acute coronary syndromes, Cardiovascular Diseases, cardiovascular events, cardiovascular outcome, coronary ischemic events, infections, Infectious disease: falciparum malaria, Infectious disease: AIDS, Infectious disease: ATL, Infectious disease: hepatitis, Infectious disease: herpes simplex, Infectious disease: syphilis, Infectious disease: TB, Inflammation, Inflammatory reactions, lymphoma, Mediastinal lympadenopathy, melanoma, myeloma, ovarian, Sepsis, neonatal infections, Non-small cell lung carcinoma
|
| Gene Ensembl |
ENSMUSG00000037942, ENSG00000132693, ENSCAFG00845030990, ENSMMUG00000008922
|
Pre-made viral vector of C-Reactive Protein/CRP cDNA Clones/ORF Plasmid
C-Reactive Protein/CRP siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo1401 | Pre-made Human CRP/PTX1 siRNA oligo Duplex | 1401 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25419 | Pre-made Rat Crp/Aa1249/Ac1262 siRNA oligo Duplex | 25419 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo12944 | Pre-made Mouse Crp siRNA oligo Duplex | 12944 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo719454 | Pre-made Cynomolgus/Rhesus macaque CRP siRNA oligo Duplex | 719454 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101093079 | Pre-made Cat/Feline CRP siRNA oligo Duplex | 101093079 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo488629 | Pre-made Dog/Canine CRP siRNA oligo Duplex | 488629 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo527553 | Pre-made Bovines/Cattle CRP siRNA oligo Duplex | 527553 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo138915014 | Pre-made Equine/Horse CRP siRNA oligo Duplex | 138915014 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
C-Reactive Protein/CRP antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-SE0824-Ab | Human | Anti-Human C-Reactive Protein/CRP monoclonal antibody | mab | FACS/Biofunctional Antibody, Diagnostic target antibody, Cytokine antibody | Detail |
| GM-Tg-rg-SE0824-Ab | Rat | Anti-Rat C-Reactive Protein/CRP monoclonal antibody | mab | FACS/Biofunctional Antibody, Diagnostic target antibody, Cytokine antibody | Detail |
| GM-Tg-mg-SE0824-Ab | Mouse | Anti-Mouse C-Reactive Protein/CRP monoclonal antibody | mab | FACS/Biofunctional Antibody, Diagnostic target antibody, Cytokine antibody | Detail |
| GM-Tg-cynog-SE0824-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque C-Reactive Protein/CRP monoclonal antibody | mab | FACS/Biofunctional Antibody, Diagnostic target antibody, Cytokine antibody | Detail |
| GM-Tg-felg-SE0824-Ab | Cat/Feline | Anti-Cat/Feline C-Reactive Protein/CRP monoclonal antibody | mab | FACS/Biofunctional Antibody, Diagnostic target antibody, Cytokine antibody | Detail |
| GM-Tg-cang-SE0824-Ab | Dog/Canine | Anti-Dog/Canine C-Reactive Protein/CRP monoclonal antibody | mab | FACS/Biofunctional Antibody, Diagnostic target antibody, Cytokine antibody | Detail |
| GM-Tg-bovg-SE0824-Ab | Bovines/Cattle | Anti-Bovines/Cattle C-Reactive Protein/CRP monoclonal antibody | mab | FACS/Biofunctional Antibody, Diagnostic target antibody, Cytokine antibody | Detail |
| GM-Tg-equg-SE0824-Ab | Equine/Horse | Anti-Equine/Horse C-Reactive Protein/CRP monoclonal antibody | mab | FACS/Biofunctional Antibody, Diagnostic target antibody, Cytokine antibody | Detail |
C-Reactive Protein/CRP recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-SE0824-Ag | Human | Human C-Reactive Protein/CRP recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-SE0824-Ag | Rat | Rat C-Reactive Protein/CRP recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-SE0824-Ag | Mouse | Mouse C-Reactive Protein/CRP recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-SE0824-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque C-Reactive Protein/CRP recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-SE0824-Ag | Cat/Feline | Cat/Feline C-Reactive Protein/CRP recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-SE0824-Ag | Dog/Canine | Dog/Canine C-Reactive Protein/CRP recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-SE0824-Ag | Bovines/Cattle | Bovines/Cattle C-Reactive Protein/CRP recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-SE0824-Ag | Equine/Horse | Equine/Horse C-Reactive Protein/CRP recombinant protein | Mammalian cell | Detail |