Explore KU70/XRCC6 gene products and cross-species
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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Secreted Protein/Potential Cytokines.
The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus. [provided by RefSeq, Jul 2008]
| Target ID |
GM-SE0563
|
| Target Name |
KU70/XRCC6
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
2547
|
| Gene ID |
100070684 (Equus caballus), 101081395 (Felis catus), 14375 (Mus musculus), 25019 (Rattus norvegicus)
2547 (Homo sapiens), 474485 (Canis lupus familiaris), 510132 (Bos taurus), 707975 (Macaca mulatta)
|
| Target Alternative Names |
5'-deoxyribose-5-phosphate lyase Ku70 (5'-dRP lyase Ku70),70 kDa subunit of Ku antigen,70kDa,ATP-dependent DNA helicase 2 subunit 1,ATP-dependent DNA helicase II 70 kDa subunit,CTC box-binding factor 75 kDa subunit (CTC75,CTC75,CTCBF,CTCBF),DNA repair protein XRCC6,G22P1,G22p1,KU70,Ku70,Kup70,Lupus Ku autoantigen protein p70 (Ku70),ML8,TLAA,Thyroid-lupus autoantigen (TLAA),X-ray repair complementing defective repair in Chinese hamster cells 6,X-ray repair cross-complementing protein 6,XRCC6,Xrcc6
|
| Uniprot Accession |
P23475,P12956
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Disease |
cancer
|
| Gene Ensembl |
ENSECAG00000017563, ENSMUSG00000022471, ENSG00000196419, ENSCAFG00845016282, ENSBTAG00000006103, ENSMMUG00000001856
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of KU70/XRCC6 cDNA Clones/ORF Plasmid
KU70/XRCC6 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo2547 | Pre-made Human XRCC6/ML8/KU70 siRNA oligo Duplex | 2547 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25019 | Pre-made Rat Xrcc6/Ku70/G22p1 siRNA oligo Duplex | 25019 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo14375 | Pre-made Mouse Xrcc6/Ku70/70kDa siRNA oligo Duplex | 14375 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo707975 | Pre-made Cynomolgus/Rhesus macaque XRCC6 siRNA oligo Duplex | 707975 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101081395 | Pre-made Cat/Feline XRCC6 siRNA oligo Duplex | 101081395 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo474485 | Pre-made Dog/Canine XRCC6/Ku70 siRNA oligo Duplex | 474485 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo510132 | Pre-made Bovines/Cattle XRCC6 siRNA oligo Duplex | 510132 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100070684 | Pre-made Equine/Horse XRCC6 siRNA oligo Duplex | 100070684 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
KU70/XRCC6 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-SE0563-Ab | Human | Anti-Human KU70/XRCC6 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-rg-SE0563-Ab | Rat | Anti-Rat KU70/XRCC6 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-mg-SE0563-Ab | Mouse | Anti-Mouse KU70/XRCC6 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cynog-SE0563-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque KU70/XRCC6 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-felg-SE0563-Ab | Cat/Feline | Anti-Cat/Feline KU70/XRCC6 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cang-SE0563-Ab | Dog/Canine | Anti-Dog/Canine KU70/XRCC6 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-bovg-SE0563-Ab | Bovines/Cattle | Anti-Bovines/Cattle KU70/XRCC6 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-equg-SE0563-Ab | Equine/Horse | Anti-Equine/Horse KU70/XRCC6 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
KU70/XRCC6 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-SE0563-Ag | Human | Human KU70/XRCC6 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-SE0563-Ag | Rat | Rat KU70/XRCC6 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-SE0563-Ag | Mouse | Mouse KU70/XRCC6 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-SE0563-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque KU70/XRCC6 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-SE0563-Ag | Cat/Feline | Cat/Feline KU70/XRCC6 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-SE0563-Ag | Dog/Canine | Dog/Canine KU70/XRCC6 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-SE0563-Ag | Bovines/Cattle | Bovines/Cattle KU70/XRCC6 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-SE0563-Ag | Equine/Horse | Equine/Horse KU70/XRCC6 recombinant protein | Mammalian cell | Detail |
