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Target
sublocation: Secreted Protein/Potential Cytokines.
This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
| Target ID |
GM-SE0440
|
| Target Name |
ASC/TMS1/PYCARD
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
29108
|
| Gene ID |
100856347 (Canis lupus familiaris), 282817 (Rattus norvegicus), 29108 (Homo sapiens), 713563 (Macaca mulatta)
|
| Target Alternative Names |
ASC,Apoptosis-associated speck-like protein containing a CARD,Asc,CARD5,Caspase recruitment domain-containing protein 5,PYCARD,PYD and CARD domain-containing protein,Pycard,TMS,TMS-1,TMS1,Target of methylation-induced silencing 1,hASC
|
| Uniprot Accession |
Q9ULZ3
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Disease |
cancer
|
| Disease from KEGG |
NOD-like receptor signaling pathway, C-type lectin receptor signaling pathway, Pathogenic Escherichia coli infection, Pertussis, Legionellosis, Yersinia infection, Influenza A, Lipid and atherosclerosis
|
| Gene Ensembl |
ENSCAFG00845011935, ENSG00000103490, ENSMMUG00000051859
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of ASC/TMS1/PYCARD cDNA Clones/ORF Plasmid
ASC/TMS1/PYCARD siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo29108 | Pre-made Human PYCARD/ASC/TMS siRNA oligo Duplex | 29108 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo282817 | Pre-made Rat Pycard/Asc siRNA oligo Duplex | 282817 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo713563 | Pre-made Cynomolgus/Rhesus macaque PYCARD siRNA oligo Duplex | 713563 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100856347 | Pre-made Dog/Canine PYCARD siRNA oligo Duplex | 100856347 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
ASC/TMS1/PYCARD antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-SE0440-Ab | Human | Anti-Human ASC/TMS1/PYCARD monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-rg-SE0440-Ab | Rat | Anti-Rat ASC/TMS1/PYCARD monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cynog-SE0440-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque ASC/TMS1/PYCARD monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cang-SE0440-Ab | Dog/Canine | Anti-Dog/Canine ASC/TMS1/PYCARD monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
ASC/TMS1/PYCARD recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-SE0440-Ag | Human | Human ASC/TMS1/PYCARD recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-SE0440-Ag | Rat | Rat ASC/TMS1/PYCARD recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-SE0440-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque ASC/TMS1/PYCARD recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-SE0440-Ag | Dog/Canine | Dog/Canine ASC/TMS1/PYCARD recombinant protein | Mammalian cell | Detail |
