Explore WNT1 gene products and cross-species
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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Transmembrane Protein.
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in the chromosome 12q13 region. [provided by RefSeq, Jul 2008]
| Target ID |
GM-MP1934
|
| Target Name |
WNT1
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
7471
|
| Gene ID |
100058859 (Equus caballus), 101094190 (Felis catus), 22408 (Mus musculus), 24881 (Rattus norvegicus) 486560 (Canis lupus familiaris), 540662 (Bos taurus), 709009 (Macaca mulatta), 7471 (Homo sapiens)
|
| Target Alternative Names |
BMND16,INT1,Int-1,Int1,OI15,Proto-oncogene Int-1 homolog,Proto-oncogene Wnt-1,WNT1,Wnt-1,Wnt1,sw,swaying
|
| Uniprot Accession |
P04426,P04628
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Cytokine Target
|
| Disease |
cancer
|
| Disease from KEGG |
Wnt signaling pathway, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells, Melanogenesis, Cushing syndrome, Alzheimer disease, Human papillomavirus infection, Pathways in cancer, Proteoglycans in cancer, Chemical carcinogenesis - receptor activation, Basal cell carcinoma, Breast cancer, Hepatocellular carcinoma, Gastric cancer
|
| Gene Ensembl |
ENSECAG00000009064, ENSMUSG00000022997, ENSCAFG00845022557, ENSBTAG00000015364, ENSMMUG00000015709, ENSG00000125084
|
| Target Classification |
Pathway, Tumor-associated antigen (TAA)
|
Pre-made viral vector of WNT1 cDNA Clones/ORF Plasmid
WNT1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo7471 | Pre-made Human WNT1/INT1/OI15 siRNA oligo Duplex | 7471 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo24881 | Pre-made Rat Wnt1/Int1 siRNA oligo Duplex | 24881 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo22408 | Pre-made Mouse Wnt1/sw/Int-1 siRNA oligo Duplex | 22408 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo709009 | Pre-made Cynomolgus/Rhesus macaque WNT1 siRNA oligo Duplex | 709009 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101094190 | Pre-made Cat/Feline WNT1 siRNA oligo Duplex | 101094190 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo486560 | Pre-made Dog/Canine WNT1 siRNA oligo Duplex | 486560 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo540662 | Pre-made Bovines/Cattle WNT1 siRNA oligo Duplex | 540662 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100058859 | Pre-made Equine/Horse WNT1 siRNA oligo Duplex | 100058859 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
WNT1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-MP1934-Ab | Human | Anti-Human WNT1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Cytokine antibody | Detail |
| GM-Tg-rg-MP1934-Ab | Rat | Anti-Rat WNT1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Cytokine antibody | Detail |
| GM-Tg-mg-MP1934-Ab | Mouse | Anti-Mouse WNT1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Cytokine antibody | Detail |
| GM-Tg-cynog-MP1934-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque WNT1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Cytokine antibody | Detail |
| GM-Tg-felg-MP1934-Ab | Cat/Feline | Anti-Cat/Feline WNT1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Cytokine antibody | Detail |
| GM-Tg-cang-MP1934-Ab | Dog/Canine | Anti-Dog/Canine WNT1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Cytokine antibody | Detail |
| GM-Tg-bovg-MP1934-Ab | Bovines/Cattle | Anti-Bovines/Cattle WNT1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Cytokine antibody | Detail |
| GM-Tg-equg-MP1934-Ab | Equine/Horse | Anti-Equine/Horse WNT1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Cytokine antibody | Detail |
WNT1 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-MP1934-Ag | Human | Human WNT1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-MP1934-Ag | Rat | Rat WNT1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-MP1934-Ag | Mouse | Mouse WNT1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-MP1934-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque WNT1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-MP1934-Ag | Cat/Feline | Cat/Feline WNT1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-MP1934-Ag | Dog/Canine | Dog/Canine WNT1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-MP1934-Ag | Bovines/Cattle | Bovines/Cattle WNT1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-MP1934-Ag | Equine/Horse | Equine/Horse WNT1 VLP (virus-like particle) | HEK293 | Products Developing |