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Target
sublocation: Introcelluar Protein.
The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Differences in the expression of this gene are associated with host susceptibility to viral infection. [provided by RefSeq, Aug 2020]
| Target ID |
GM-IP0076
|
| Target Name |
FUT3
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
2525
|
| Gene ID |
2525 (Homo sapiens)
|
| Target Alternative Names |
3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3,4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase,Alpha-3-fucosyltransferase FUT3,Blood group Lewis alpha-4-fucosyltransferase (Lewis FT),CD174,FT3B,FUT3,FucT-III,Fucosyltransferase 3,Fucosyltransferase III (FucT-III),LE,Les
|
| Uniprot Accession |
P21217
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target
|
| Disease from KEGG |
Metabolic pathways, Glycosphingolipid biosynthesis - lacto and neolacto series
|
| Gene Ensembl |
ENSG00000171124
|
| Target Classification |
Checkpoint-Immuno Oncology
|
Pre-made viral vector of FUT3 cDNA Clones/ORF Plasmid
FUT3 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo2525 | Pre-made Human FUT3/LE/Les siRNA oligo Duplex | 2525 | Human | In-vitro grade; in-vivo grade | Detail |
FUT3 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-IP0076-Ab | Human | Anti-Human FUT3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
FUT3 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-IP0076-Ag | Human | Human FUT3 recombinant protein | Mammalian cell | Detail |
