Explore BCL2/BCL-2 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Introcelluar Protein.
This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
| Target ID |
GM-IP0014
|
| Target Name |
BCL2/BCL-2
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
596
|
| Gene ID |
100050934 (Equus caballus), 12043 (Mus musculus), 24224 (Rattus norvegicus), 281020 (Bos taurus)
403416 (Canis lupus familiaris), 493934 (Felis catus), 596 (Homo sapiens), 707407 (Macaca mulatta)
|
| Target Alternative Names |
Apoptosis regulator Bcl-2,BCL-2,BCL2,Bcl-2,Bcl2,C430015F12Rik,D630044D05Rik,D830018M01Rik,PPP1R50,bcl-2
|
| Uniprot Accession |
P10417,P49950,O02718,Q6R755,P10415
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target
|
| Disease |
cancer, Breast Cancer, immune cells or tumors
|
| Disease from KEGG |
EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, NF-kappa B signaling pathway, HIF-1 signaling pathway, Sphingolipid signaling pathway, p53 signaling pathway, Protein processing in endoplasmic reticulum, PI3K-Akt signaling pathway, Apoptosis, Apoptosis - multiple species, Adrenergic signaling in cardiomyocytes, Focal adhesion, NOD-like receptor signaling pathway, JAK-STAT signaling pathway, Neurotrophin signaling pathway, Cholinergic synapse, Parathyroid hormone synthesis, secretion and action, AGE-RAGE signaling pathway in diabetic complications, Toxoplasmosis, Tuberculosis, Hepatitis B, Measles, Epstein-Barr virus infection, Pathways in cancer, Chemical carcinogenesis - receptor activation, Colorectal cancer, Prostate cancer, Small cell lung cancer, Gastric cancer, Lipid and atherosclerosis, Fluid shear stress and atherosclerosis
|
| Gene Ensembl |
ENSECAG00000020437, ENSMUSG00000057329, ENSBTAG00000019302, ENSCAFG00845002725, ENSG00000171791, ENSMMUG00000059194
|
| Target Classification |
Pathway, Checkpoint-Immuno Oncology
|
Pre-made viral vector of BCL2/BCL-2 cDNA Clones/ORF Plasmid
BCL2/BCL-2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo596 | Pre-made Human BCL2/Bcl-2/PPP1R50 siRNA oligo Duplex | 596 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo24224 | Pre-made Rat Bcl2/Bcl-2 siRNA oligo Duplex | 24224 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo12043 | Pre-made Mouse Bcl2/Bcl-2/C430015F12Rik siRNA oligo Duplex | 12043 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo707407 | Pre-made Cynomolgus/Rhesus macaque BCL2 siRNA oligo Duplex | 707407 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo493934 | Pre-made Cat/Feline BCL2/bcl-2 siRNA oligo Duplex | 493934 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo403416 | Pre-made Dog/Canine BCL2/BCL-2 siRNA oligo Duplex | 403416 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo281020 | Pre-made Bovines/Cattle BCL2 siRNA oligo Duplex | 281020 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100050934 | Pre-made Equine/Horse BCL2 siRNA oligo Duplex | 100050934 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
BCL2/BCL-2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-IP0014-Ab | Human | Anti-Human BCL2/BCL-2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-IP0014-Ab | Rat | Anti-Rat BCL2/BCL-2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-IP0014-Ab | Mouse | Anti-Mouse BCL2/BCL-2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-IP0014-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque BCL2/BCL-2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-IP0014-Ab | Cat/Feline | Anti-Cat/Feline BCL2/BCL-2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-IP0014-Ab | Dog/Canine | Anti-Dog/Canine BCL2/BCL-2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-IP0014-Ab | Bovines/Cattle | Anti-Bovines/Cattle BCL2/BCL-2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-IP0014-Ab | Equine/Horse | Anti-Equine/Horse BCL2/BCL-2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
BCL2/BCL-2 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-IP0014-Ag | Human | Human BCL2/BCL-2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-IP0014-Ag | Rat | Rat BCL2/BCL-2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-IP0014-Ag | Mouse | Mouse BCL2/BCL-2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-IP0014-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque BCL2/BCL-2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-IP0014-Ag | Cat/Feline | Cat/Feline BCL2/BCL-2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-IP0014-Ag | Dog/Canine | Dog/Canine BCL2/BCL-2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-IP0014-Ag | Bovines/Cattle | Bovines/Cattle BCL2/BCL-2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-IP0014-Ag | Equine/Horse | Equine/Horse BCL2/BCL-2 recombinant protein | Mammalian cell | Detail |
