Recombinant multi-species POLG protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine POLG protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit. The protein encoded by this gene is the catalytic subunit of mitochondrial DNA polymerase. The encoded protein contains a polyglutamine tract near its N-terminus that may be polymorphic. Defects in this gene are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions 1 (PEOA1), sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO), Alpers-Huttenlocher syndrome (AHS), and mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE). Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
The Alternative Names of target: POLG,DNA polymerase subunit gamma-1,3'-5' exodeoxyribonuclease, 5'-deoxyribose-phosphate lyase, Mitochondrial DNA polymerase catalytic subunit, PolG-alpha,PEO,MDP1,SCAE,MIRAS,POLG1,POLGA,SANDO,MTDPS4A,MTDPS4B

Target products collectionGo to POLG products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-TA183-Ab-1/ GM-Tg-hg-TA183-Ab-2 Human POLG protein Human
GM-Tg-rg-TA183-Ab-1/ GM-Tg-rg-TA183-Ab-2 Rat POLG protein Rat
GM-Tg-mg-TA183-Ab-1/ GM-Tg-mg-TA183-Ab-2 Mouse POLG protein Mouse
GM-Tg-cynog-TA183-Ab-1/ GM-Tg-cynog-TA183-Ab-2 Cynomolgus/Rhesus macaque POLG monoclonal antibody Cynomolgus/ Rhesus macaque
GM-Tg-felg-TA183-Ab-1/ GM-Tg-felg-TA183-Ab-2 Feline POLG protein Feline
GM-Tg-cang-TA183-Ab-1/ GM-Tg-cang-TA183-Ab-2 Canine POLG protein Canine
GM-Tg-bovg-TA183-Ab-1/ GM-Tg-bovg-TA183-Ab-2 Bovine POLG protein Bovine
GM-Tg-equg-TA183-Ab-1/ GM-Tg-equg-TA183-Ab-2 Equine POLG protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-TA183-Ab-1/ GM-Tg-hg-TA183-Ab-2; GM-Tg-rg-TA183-Ab-1/ GM-Tg-rg-TA183-Ab-2;
GM-Tg-mg-TA183-Ab-1/ GM-Tg-mg-TA183-Ab-2; GM-Tg-cynog-TA183-Ab-1/ GM-Tg-cynog-TA183-Ab-2;
GM-Tg-felg-TA183-Ab-1/ GM-Tg-felg-TA183-Ab-2; GM-Tg-cang-TA183-Ab-1/ GM-Tg-cang-TA183-Ab-2;
GM-Tg-bovg-TA183-Ab-1/ GM-Tg-bovg-TA183-Ab-2; GM-Tg-equg-TA183-Ab-1/ GM-Tg-equg-TA183-Ab-2
Products Name POLG protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name POLG
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine POLG protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
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