Recombinant multi-species STAT5A protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine STAT5A protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]
The Alternative Names of target: MGF,STAT5,STAT5A,Signal transducer and activator of transcription 5A,Stat5a

Target products collectionGo to STAT5A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-TA046-Ag-1/ GM-Tg-hg-TA046-Ag-2 Human STAT5A protein Human
GM-Tg-rg-TA046-Ag-1/ GM-Tg-rg-TA046-Ag-2 Rat STAT5A protein Rat
GM-Tg-mg-TA046-Ag-1/ GM-Tg-mg-TA046-Ag-2 Mouse STAT5A protein Mouse
GM-Tg-cynog-TA046-Ag-1/ GM-Tg-cynog-TA046-Ag-2 Cynomolgus/Rhesus macaque STAT5A protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-TA046-Ag-1/ GM-Tg-felg-TA046-Ag-2 Feline STAT5A protein Feline
GM-Tg-cang-TA046-Ag-1/ GM-Tg-cang-TA046-Ag-2 Canine STAT5A protein Canine
GM-Tg-bovg-TA046-Ag-1/ GM-Tg-bovg-TA046-Ag-2 Bovine STAT5A protein Bovine
GM-Tg-equg-TA046-Ag-1/ GM-Tg-equg-TA046-Ag-2 Equine STAT5A protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-TA046-Ag-1/ GM-Tg-hg-TA046-Ag-2; GM-Tg-rg-TA046-Ag-1/ GM-Tg-rg-TA046-Ag-2;
GM-Tg-mg-TA046-Ag-1/ GM-Tg-mg-TA046-Ag-2; GM-Tg-cynog-TA046-Ag-1/ GM-Tg-cynog-TA046-Ag-2;
GM-Tg-felg-TA046-Ag-1/ GM-Tg-felg-TA046-Ag-2; GM-Tg-cang-TA046-Ag-1/ GM-Tg-cang-TA046-Ag-2;
GM-Tg-bovg-TA046-Ag-1/ GM-Tg-bovg-TA046-Ag-2; GM-Tg-equg-TA046-Ag-1/ GM-Tg-equg-TA046-Ag-2
Products Name STAT5A protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name STAT5A
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine STAT5A protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.