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Target
sublocation: Introcelluar Protein.
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]
| Target ID |
GM-TA046
|
| Target Name |
STAT5A
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
6776
|
| Gene ID |
20850 (Mus musculus), 6776 (Homo sapiens)
|
| Target Alternative Names |
MGF,STAT5,STAT5A,Signal transducer and activator of transcription 5A,Stat5a
|
| Uniprot Accession |
P42230,P42229
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target
|
| Disease |
cancer
|
| Disease from KEGG |
ErbB signaling pathway, JAK-STAT signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Prolactin signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Growth hormone synthesis, secretion and action, Hepatitis B, Measles, Human T-cell leukemia virus 1 infection, Pathways in cancer, Chemical carcinogenesis - receptor activation, Chronic myeloid leukemia, Acute myeloid leukemia, Non-small cell lung cancer
|
| Gene Ensembl |
ENSMUSG00000004043, ENSG00000126561
|
| Target Classification |
Checkpoint-Immuno Oncology, Tumor-associated antigen (TAA)
|
Pre-made viral vector of STAT5A cDNA Clones/ORF Plasmid
STAT5A siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo6776 | Pre-made Human STAT5A/MGF/STAT5 siRNA oligo Duplex | 6776 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo20850 | Pre-made Mouse Stat5a/STAT5 siRNA oligo Duplex | 20850 | Mouse | In-vitro grade; in-vivo grade | Detail |
STAT5A antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-TA046-Ab | Human | Anti-Human STAT5A monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-TA046-Ab | Mouse | Anti-Mouse STAT5A monoclonal antibody | mab | Therapeutics Target antibody | Detail |
STAT5A recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-TA046-Ag | Human | Human STAT5A recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-TA046-Ag | Mouse | Mouse STAT5A recombinant protein | Mammalian cell | Detail |
