Recombinant multi-species Thrombopoietin/THPO protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine Thrombopoietin/THPO protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Megakaryocytopoiesis is the cellular development process that leads to platelet production. The main functional protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Mutations in this gene are the cause of thrombocythemia 1. Alternative promoter usage and differential splicing result in multiple transcript variants differing in the 5' UTR and/or coding region. Multiple AUG codons upstream of the main open reading frame (ORF) have been identified, and these upstream AUGs inhibit translation of the main ORF at different extent. [provided by RefSeq, Feb 2014]
The Alternative Names of target: C-mpl ligand (ML),CAMT2,MGDF,MKCSF,ML,MPLLG,Megakaryocyte colony-stimulating factor,Megakaryocyte growth and development factor (MGDF),Mgdf,Ml,Mpllg,Myeloproliferative leukemia virus oncogene ligand,THC9,THCYT1,THPO,TPO,Thpo,Thpol1,Thrombopoietin,Tpo

Target products collectionGo to Thrombopoietin/THPO products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T99379-Ag-1/ GM-Tg-hg-T99379-Ag-2 Human Thrombopoietin/THPO protein Human
GM-Tg-rg-T99379-Ag-1/ GM-Tg-rg-T99379-Ag-2 Rat Thrombopoietin/THPO protein Rat
GM-Tg-mg-T99379-Ag-1/ GM-Tg-mg-T99379-Ag-2 Mouse Thrombopoietin/THPO protein Mouse
GM-Tg-cynog-T99379-Ag-1/ GM-Tg-cynog-T99379-Ag-2 Cynomolgus/Rhesus macaque Thrombopoietin/THPO protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T99379-Ag-1/ GM-Tg-felg-T99379-Ag-2 Feline Thrombopoietin/THPO protein Feline
GM-Tg-cang-T99379-Ag-1/ GM-Tg-cang-T99379-Ag-2 Canine Thrombopoietin/THPO protein Canine
GM-Tg-bovg-T99379-Ag-1/ GM-Tg-bovg-T99379-Ag-2 Bovine Thrombopoietin/THPO protein Bovine
GM-Tg-equg-T99379-Ag-1/ GM-Tg-equg-T99379-Ag-2 Equine Thrombopoietin/THPO protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T99379-Ag-1/ GM-Tg-hg-T99379-Ag-2; GM-Tg-rg-T99379-Ag-1/ GM-Tg-rg-T99379-Ag-2;
GM-Tg-mg-T99379-Ag-1/ GM-Tg-mg-T99379-Ag-2; GM-Tg-cynog-T99379-Ag-1/ GM-Tg-cynog-T99379-Ag-2;
GM-Tg-felg-T99379-Ag-1/ GM-Tg-felg-T99379-Ag-2; GM-Tg-cang-T99379-Ag-1/ GM-Tg-cang-T99379-Ag-2;
GM-Tg-bovg-T99379-Ag-1/ GM-Tg-bovg-T99379-Ag-2; GM-Tg-equg-T99379-Ag-1/ GM-Tg-equg-T99379-Ag-2
Products Name Thrombopoietin/THPO protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name Thrombopoietin/THPO
Protein Sub-location Secreted Protein/Potential Cytokines
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine Thrombopoietin/THPO protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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