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Target
sublocation: Secreted Protein/Potential Cytokines.
Megakaryocytopoiesis is the cellular development process that leads to platelet production. The main functional protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Mutations in this gene are the cause of thrombocythemia 1. Alternative promoter usage and differential splicing result in multiple transcript variants differing in the 5' UTR and/or coding region. Multiple AUG codons upstream of the main open reading frame (ORF) have been identified, and these upstream AUGs inhibit translation of the main ORF at different extent. [provided by RefSeq, Feb 2014]
| Target ID |
GM-T99379
|
| Target Name |
Thrombopoietin/THPO
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
7066
|
| Gene ID |
100059159 (Equus caballus), 100302539 (Felis catus), 100428640 (Macaca mulatta), 100855822 (Canis lupus familiaris) 21832 (Mus musculus), 538672 (Bos taurus), 7066 (Homo sapiens), 81811 (Rattus norvegicus)
|
| Target Alternative Names |
C-mpl ligand (ML),CAMT2,MGDF,MKCSF,ML,MPLLG,Megakaryocyte colony-stimulating factor,Megakaryocyte growth and development factor (MGDF),Mgdf,Ml,Mpllg,Myeloproliferative leukemia virus oncogene ligand,THC9,THCYT1,THPO,TPO,Thpo,Thpol1,Thrombopoietin,Tpo
|
| Uniprot Accession |
P42705,P40226,P40225,P49745
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Category |
Therapeutics Target
|
| Disease |
leukemia
|
| Disease from KEGG |
Cytokine-cytokine receptor interaction, JAK-STAT signaling pathway, Hematopoietic cell lineage
|
| Gene Ensembl |
ENSECAG00000005883, ENSCAFG00845028504, ENSMUSG00000022847, ENSBTAG00000000476, ENSG00000090534
|
Pre-made viral vector of Thrombopoietin/THPO cDNA Clones/ORF Plasmid
Thrombopoietin/THPO siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo7066 | Pre-made Human THPO/ML/TPO siRNA oligo Duplex | 7066 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo81811 | Pre-made Rat Thpol1/Thpo siRNA oligo Duplex | 81811 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo21832 | Pre-made Mouse Thpo/Ml/Tpo siRNA oligo Duplex | 21832 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100428640 | Pre-made Cynomolgus/Rhesus macaque THPO siRNA oligo Duplex | 100428640 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100302539 | Pre-made Cat/Feline THPO/TPO siRNA oligo Duplex | 100302539 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100855822 | Pre-made Dog/Canine THPO/ML/TPO siRNA oligo Duplex | 100855822 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo538672 | Pre-made Bovines/Cattle THPO siRNA oligo Duplex | 538672 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100059159 | Pre-made Equine/Horse THPO siRNA oligo Duplex | 100059159 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
Thrombopoietin/THPO antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T99379-Ab | Human | Anti-Human Thrombopoietin/THPO monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T99379-Ab | Rat | Anti-Rat Thrombopoietin/THPO monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T99379-Ab | Mouse | Anti-Mouse Thrombopoietin/THPO monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T99379-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque Thrombopoietin/THPO monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T99379-Ab | Cat/Feline | Anti-Cat/Feline Thrombopoietin/THPO monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T99379-Ab | Dog/Canine | Anti-Dog/Canine Thrombopoietin/THPO monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T99379-Ab | Bovines/Cattle | Anti-Bovines/Cattle Thrombopoietin/THPO monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T99379-Ab | Equine/Horse | Anti-Equine/Horse Thrombopoietin/THPO monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
Thrombopoietin/THPO recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T99379-Ag | Human | Human Thrombopoietin/THPO recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T99379-Ag | Rat | Rat Thrombopoietin/THPO recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T99379-Ag | Mouse | Mouse Thrombopoietin/THPO recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T99379-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque Thrombopoietin/THPO recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T99379-Ag | Cat/Feline | Cat/Feline Thrombopoietin/THPO recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T99379-Ag | Dog/Canine | Dog/Canine Thrombopoietin/THPO recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T99379-Ag | Bovines/Cattle | Bovines/Cattle Thrombopoietin/THPO recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T99379-Ag | Equine/Horse | Equine/Horse Thrombopoietin/THPO recombinant protein | Mammalian cell | Detail |