Recombinant multi-species BRAF protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine BRAF protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. A pseudogene of this gene has been identified on the X chromosome. [provided by RefSeq, Aug 2017]
The Alternative Names of target: 9930012E13Rik,B-RAF1,B-raf,BRAF,BRAF-1,BRAF1,Braf,Braf-2,Braf2,C230098H17,D6Ertd631e,NS7,Proto-oncogene B-Raf,RAFB1,Serine/threonine-protein kinase B-raf,p94,v-Raf murine sarcoma viral oncogene homolog B1

Target products collectionGo to BRAF products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T99089-Ag-1/ GM-Tg-hg-T99089-Ag-2 Human BRAF protein Human
GM-Tg-rg-T99089-Ag-1/ GM-Tg-rg-T99089-Ag-2 Rat BRAF protein Rat
GM-Tg-mg-T99089-Ag-1/ GM-Tg-mg-T99089-Ag-2 Mouse BRAF protein Mouse
GM-Tg-cynog-T99089-Ag-1/ GM-Tg-cynog-T99089-Ag-2 Cynomolgus/Rhesus macaque BRAF protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T99089-Ag-1/ GM-Tg-felg-T99089-Ag-2 Feline BRAF protein Feline
GM-Tg-cang-T99089-Ag-1/ GM-Tg-cang-T99089-Ag-2 Canine BRAF protein Canine
GM-Tg-bovg-T99089-Ag-1/ GM-Tg-bovg-T99089-Ag-2 Bovine BRAF protein Bovine
GM-Tg-equg-T99089-Ag-1/ GM-Tg-equg-T99089-Ag-2 Equine BRAF protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T99089-Ag-1/ GM-Tg-hg-T99089-Ag-2; GM-Tg-rg-T99089-Ag-1/ GM-Tg-rg-T99089-Ag-2;
GM-Tg-mg-T99089-Ag-1/ GM-Tg-mg-T99089-Ag-2; GM-Tg-cynog-T99089-Ag-1/ GM-Tg-cynog-T99089-Ag-2;
GM-Tg-felg-T99089-Ag-1/ GM-Tg-felg-T99089-Ag-2; GM-Tg-cang-T99089-Ag-1/ GM-Tg-cang-T99089-Ag-2;
GM-Tg-bovg-T99089-Ag-1/ GM-Tg-bovg-T99089-Ag-2; GM-Tg-equg-T99089-Ag-1/ GM-Tg-equg-T99089-Ag-2
Products Name BRAF protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name BRAF
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine BRAF protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.