Recombinant multi-species SIRT3 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine SIRT3 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
SIRT3 encodes a member of the sirtuin family of class III histone deacetylases, homologs to the yeast Sir2 protein. The encoded protein is found exclusively in mitochondria, where it can eliminate reactive oxygen species, inhibit apoptosis, and prevent the formation of cancer cells. SIRT3 has far-reaching effects on nuclear gene expression, cancer, cardiovascular disease, neuroprotection, aging, and metabolic control. [provided by RefSeq, May 2019]
The Alternative Names of target: 2310003L23Rik,NAD-dependent protein deacetylase sirtuin-3,NAD-dependent protein delactylase sirtuin-3,Regulatory protein SIR2 homolog 3,SIR2-like protein 3,SIR2L3,SIRT3,Sir2l3,Sirt3,hSIRT3,mitochondrial

Target products collectionGo to SIRT3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T91959-Ag-1/ GM-Tg-hg-T91959-Ag-2 Human SIRT3 protein Human
GM-Tg-rg-T91959-Ag-1/ GM-Tg-rg-T91959-Ag-2 Rat SIRT3 protein Rat
GM-Tg-mg-T91959-Ag-1/ GM-Tg-mg-T91959-Ag-2 Mouse SIRT3 protein Mouse
GM-Tg-cynog-T91959-Ag-1/ GM-Tg-cynog-T91959-Ag-2 Cynomolgus/Rhesus macaque SIRT3 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T91959-Ag-1/ GM-Tg-felg-T91959-Ag-2 Feline SIRT3 protein Feline
GM-Tg-cang-T91959-Ag-1/ GM-Tg-cang-T91959-Ag-2 Canine SIRT3 protein Canine
GM-Tg-bovg-T91959-Ag-1/ GM-Tg-bovg-T91959-Ag-2 Bovine SIRT3 protein Bovine
GM-Tg-equg-T91959-Ag-1/ GM-Tg-equg-T91959-Ag-2 Equine SIRT3 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T91959-Ag-1/ GM-Tg-hg-T91959-Ag-2; GM-Tg-rg-T91959-Ag-1/ GM-Tg-rg-T91959-Ag-2;
GM-Tg-mg-T91959-Ag-1/ GM-Tg-mg-T91959-Ag-2; GM-Tg-cynog-T91959-Ag-1/ GM-Tg-cynog-T91959-Ag-2;
GM-Tg-felg-T91959-Ag-1/ GM-Tg-felg-T91959-Ag-2; GM-Tg-cang-T91959-Ag-1/ GM-Tg-cang-T91959-Ag-2;
GM-Tg-bovg-T91959-Ag-1/ GM-Tg-bovg-T91959-Ag-2; GM-Tg-equg-T91959-Ag-1/ GM-Tg-equg-T91959-Ag-2
Products Name SIRT3 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name SIRT3
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine SIRT3 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.