Recombinant multi-species CYP17A1/S17AH protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CYP17A1/S17AH protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia. [provided by RefSeq, Jul 2008]
The Alternative Names of target: 17-alpha-hydroxyprogesterone aldolase,20 lyase,CPT7,CYP17,CYP17A1,CYPXVII,Cyp17,Cyp17a1,Cytochrome P450 17A1,Cytochrome P450-C17 (Cytochrome P450c17),P450-C17,P45017A1,P450C17,P450c17,S17AH,Steroid 17-alpha-hydroxylase/17,Steroid 17-alpha-monooxygenase,p450c17

Target products collectionGo to CYP17A1/S17AH products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T89041-Ag-1/ GM-Tg-hg-T89041-Ag-2 Human CYP17A1/S17AH protein Human
GM-Tg-rg-T89041-Ag-1/ GM-Tg-rg-T89041-Ag-2 Rat CYP17A1/S17AH protein Rat
GM-Tg-mg-T89041-Ag-1/ GM-Tg-mg-T89041-Ag-2 Mouse CYP17A1/S17AH protein Mouse
GM-Tg-cynog-T89041-Ag-1/ GM-Tg-cynog-T89041-Ag-2 Cynomolgus/Rhesus macaque CYP17A1/S17AH protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T89041-Ag-1/ GM-Tg-felg-T89041-Ag-2 Feline CYP17A1/S17AH protein Feline
GM-Tg-cang-T89041-Ag-1/ GM-Tg-cang-T89041-Ag-2 Canine CYP17A1/S17AH protein Canine
GM-Tg-bovg-T89041-Ag-1/ GM-Tg-bovg-T89041-Ag-2 Bovine CYP17A1/S17AH protein Bovine
GM-Tg-equg-T89041-Ag-1/ GM-Tg-equg-T89041-Ag-2 Equine CYP17A1/S17AH protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T89041-Ag-1/ GM-Tg-hg-T89041-Ag-2; GM-Tg-rg-T89041-Ag-1/ GM-Tg-rg-T89041-Ag-2;
GM-Tg-mg-T89041-Ag-1/ GM-Tg-mg-T89041-Ag-2; GM-Tg-cynog-T89041-Ag-1/ GM-Tg-cynog-T89041-Ag-2;
GM-Tg-felg-T89041-Ag-1/ GM-Tg-felg-T89041-Ag-2; GM-Tg-cang-T89041-Ag-1/ GM-Tg-cang-T89041-Ag-2;
GM-Tg-bovg-T89041-Ag-1/ GM-Tg-bovg-T89041-Ag-2; GM-Tg-equg-T89041-Ag-1/ GM-Tg-equg-T89041-Ag-2
Products Name CYP17A1/S17AH protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name CYP17A1/S17AH
Protein Sub-location Secreted Protein/Potential Cytokines
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CYP17A1/S17AH protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
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