Recombinant multi-species NODAL protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine NODAL protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which regulates early embryonic development. This protein is required for maintenance of human embryonic stem cell pluripotency and may play a role in human placental development. Mutations in this gene are associated with heterotaxy, a condition characterized by random orientation of visceral organs with respect to the left-right axis. [provided by RefSeq, Aug 2016]
The Alternative Names of target: HTX5,NODAL,Nodal,Nodal homolog,Tg.413d

Target products collectionGo to NODAL products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T87448-Ag-1/ GM-Tg-hg-T87448-Ag-2 Human NODAL protein Human
GM-Tg-rg-T87448-Ag-1/ GM-Tg-rg-T87448-Ag-2 Rat NODAL protein Rat
GM-Tg-mg-T87448-Ag-1/ GM-Tg-mg-T87448-Ag-2 Mouse NODAL protein Mouse
GM-Tg-cynog-T87448-Ag-1/ GM-Tg-cynog-T87448-Ag-2 Cynomolgus/Rhesus macaque NODAL protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T87448-Ag-1/ GM-Tg-felg-T87448-Ag-2 Feline NODAL protein Feline
GM-Tg-cang-T87448-Ag-1/ GM-Tg-cang-T87448-Ag-2 Canine NODAL protein Canine
GM-Tg-bovg-T87448-Ag-1/ GM-Tg-bovg-T87448-Ag-2 Bovine NODAL protein Bovine
GM-Tg-equg-T87448-Ag-1/ GM-Tg-equg-T87448-Ag-2 Equine NODAL protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T87448-Ag-1/ GM-Tg-hg-T87448-Ag-2; GM-Tg-rg-T87448-Ag-1/ GM-Tg-rg-T87448-Ag-2;
GM-Tg-mg-T87448-Ag-1/ GM-Tg-mg-T87448-Ag-2; GM-Tg-cynog-T87448-Ag-1/ GM-Tg-cynog-T87448-Ag-2;
GM-Tg-felg-T87448-Ag-1/ GM-Tg-felg-T87448-Ag-2; GM-Tg-cang-T87448-Ag-1/ GM-Tg-cang-T87448-Ag-2;
GM-Tg-bovg-T87448-Ag-1/ GM-Tg-bovg-T87448-Ag-2; GM-Tg-equg-T87448-Ag-1/ GM-Tg-equg-T87448-Ag-2
Products Name NODAL protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name NODAL
Protein Sub-location Secreted Protein/Potential Cytokines
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine NODAL protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.