Explore NODAL gene products and cross-species
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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Secreted Protein/Potential Cytokines.
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which regulates early embryonic development. This protein is required for maintenance of human embryonic stem cell pluripotency and may play a role in human placental development. Mutations in this gene are associated with heterotaxy, a condition characterized by random orientation of visceral organs with respect to the left-right axis. [provided by RefSeq, Aug 2016]
| Target ID |
GM-T87448
|
| Target Name |
NODAL
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
4838
|
| Gene ID |
100072735 (Equus caballus), 101096673 (Felis catus), 18119 (Mus musculus), 294503 (Rattus norvegicus)
4838 (Homo sapiens), 489028 (Canis lupus familiaris), 530748 (Bos taurus), 710424 (Macaca mulatta)
|
| Target Alternative Names |
HTX5,NODAL,Nodal,Nodal homolog,Tg.413d
|
| Uniprot Accession |
P43021,Q96S42
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells
|
| Gene Ensembl |
ENSECAG00000017055, ENSMUSG00000037171, ENSG00000156574, ENSBTAG00000013090, ENSMMUG00000023171
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of NODAL cDNA Clones/ORF Plasmid
NODAL siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo4838 | Pre-made Human NODAL/HTX5 siRNA oligo Duplex | 4838 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo294503 | Pre-made Rat Nodal siRNA oligo Duplex | 294503 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo18119 | Pre-made Mouse Nodal/Tg.413d siRNA oligo Duplex | 18119 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo710424 | Pre-made Cynomolgus/Rhesus macaque NODAL siRNA oligo Duplex | 710424 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101096673 | Pre-made Cat/Feline NODAL siRNA oligo Duplex | 101096673 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo489028 | Pre-made Dog/Canine NODAL siRNA oligo Duplex | 489028 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo530748 | Pre-made Bovines/Cattle NODAL siRNA oligo Duplex | 530748 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100072735 | Pre-made Equine/Horse NODAL siRNA oligo Duplex | 100072735 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
NODAL antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T87448-Ab | Human | Anti-Human NODAL monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T87448-Ab | Rat | Anti-Rat NODAL monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T87448-Ab | Mouse | Anti-Mouse NODAL monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T87448-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque NODAL monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T87448-Ab | Cat/Feline | Anti-Cat/Feline NODAL monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T87448-Ab | Dog/Canine | Anti-Dog/Canine NODAL monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T87448-Ab | Bovines/Cattle | Anti-Bovines/Cattle NODAL monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T87448-Ab | Equine/Horse | Anti-Equine/Horse NODAL monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
NODAL recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T87448-Ag | Human | Human NODAL recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T87448-Ag | Rat | Rat NODAL recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T87448-Ag | Mouse | Mouse NODAL recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T87448-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque NODAL recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T87448-Ag | Cat/Feline | Cat/Feline NODAL recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T87448-Ag | Dog/Canine | Dog/Canine NODAL recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T87448-Ag | Bovines/Cattle | Bovines/Cattle NODAL recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T87448-Ag | Equine/Horse | Equine/Horse NODAL recombinant protein | Mammalian cell | Detail |
