Recombinant multi-species APOH protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine APOH protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Apolipoprotein H, also known as beta-2-glycoprotein I, is a component of circulating plasma lipoproteins. It has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, hemostasis, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome (APS). The anti-beta (2) glycoprotein I antibodies from APS patients, mediate inhibition of activated protein C which has anticoagulant properties. Because beta-2-GPI is the main autoantigen in patients with APS, the disruption of this pathway by autoantibodies may be an important mechanism for thrombosis in patients with APS.[provided by RefSeq, Dec 2019]
The Alternative Names of target: APC inhibitor,APOH,Activated protein C-binding protein,Anticardiolipin cofactor,Apoh,Apolipoprotein H (Apo-H),B2G1,B2GP1,B2GPI,BG,Beta(2)GPI),Beta-2-glycoprotein 1,Beta-2-glycoprotein I (B2GPI,beta-2-GPI,beta2-GPI

Target products collectionGo to APOH products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T86885-Ag-1/ GM-Tg-hg-T86885-Ag-2 Human APOH protein Human
GM-Tg-rg-T86885-Ag-1/ GM-Tg-rg-T86885-Ag-2 Rat APOH protein Rat
GM-Tg-mg-T86885-Ag-1/ GM-Tg-mg-T86885-Ag-2 Mouse APOH protein Mouse
GM-Tg-cynog-T86885-Ag-1/ GM-Tg-cynog-T86885-Ag-2 Cynomolgus/Rhesus macaque APOH protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T86885-Ag-1/ GM-Tg-felg-T86885-Ag-2 Feline APOH protein Feline
GM-Tg-cang-T86885-Ag-1/ GM-Tg-cang-T86885-Ag-2 Canine APOH protein Canine
GM-Tg-bovg-T86885-Ag-1/ GM-Tg-bovg-T86885-Ag-2 Bovine APOH protein Bovine
GM-Tg-equg-T86885-Ag-1/ GM-Tg-equg-T86885-Ag-2 Equine APOH protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T86885-Ag-1/ GM-Tg-hg-T86885-Ag-2; GM-Tg-rg-T86885-Ag-1/ GM-Tg-rg-T86885-Ag-2;
GM-Tg-mg-T86885-Ag-1/ GM-Tg-mg-T86885-Ag-2; GM-Tg-cynog-T86885-Ag-1/ GM-Tg-cynog-T86885-Ag-2;
GM-Tg-felg-T86885-Ag-1/ GM-Tg-felg-T86885-Ag-2; GM-Tg-cang-T86885-Ag-1/ GM-Tg-cang-T86885-Ag-2;
GM-Tg-bovg-T86885-Ag-1/ GM-Tg-bovg-T86885-Ag-2; GM-Tg-equg-T86885-Ag-1/ GM-Tg-equg-T86885-Ag-2
Products Name APOH protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name APOH
Protein Sub-location Secreted Protein/Potential Cytokines
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine APOH protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

    GDU
    GDU

    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.