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Target
sublocation: Secreted Protein/Potential Cytokines.
Apolipoprotein H, also known as beta-2-glycoprotein I, is a component of circulating plasma lipoproteins. It has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, hemostasis, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome (APS). The anti-beta (2) glycoprotein I antibodies from APS patients, mediate inhibition of activated protein C which has anticoagulant properties. Because beta-2-GPI is the main autoantigen in patients with APS, the disruption of this pathway by autoantibodies may be an important mechanism for thrombosis in patients with APS.[provided by RefSeq, Dec 2019]
| Target ID |
GM-T86885
|
| Target Name |
APOH
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
350
|
| Gene ID |
100063250 (Equus caballus), 101080593 (Felis catus), 11818 (Mus musculus), 281006 (Bos taurus) 287774 (Rattus norvegicus), 350 (Homo sapiens), 403945 (Canis lupus familiaris), 718645 (Macaca mulatta)
|
| Target Alternative Names |
APC inhibitor,APOH,Activated protein C-binding protein,Anticardiolipin cofactor,Apoh,Apolipoprotein H (Apo-H),B2G1,B2GP1,B2GPI,BG,Beta(2)GPI),Beta-2-glycoprotein 1,Beta-2-glycoprotein I (B2GPI,beta-2-GPI,beta2-GPI
|
| Uniprot Accession |
Q01339,P17690,P26644,P02749,P33703
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
Cholesterol metabolism
|
| Gene Ensembl |
ENSECAG00000022165, ENSMUSG00000000049, ENSBTAG00000001915, ENSG00000091583, ENSCAFG00845028150, ENSMMUG00000015120
|
Pre-made viral vector of APOH cDNA Clones/ORF Plasmid
APOH siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo350 | Pre-made Human APOH/BG/B2G1 siRNA oligo Duplex | 350 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo287774 | Pre-made Rat Apoh siRNA oligo Duplex | 287774 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo11818 | Pre-made Mouse Apoh/B2GPI/beta2-GPI siRNA oligo Duplex | 11818 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo718645 | Pre-made Cynomolgus/Rhesus macaque APOH siRNA oligo Duplex | 718645 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101080593 | Pre-made Cat/Feline APOH siRNA oligo Duplex | 101080593 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo403945 | Pre-made Dog/Canine APOH siRNA oligo Duplex | 403945 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo281006 | Pre-made Bovines/Cattle APOH siRNA oligo Duplex | 281006 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100063250 | Pre-made Equine/Horse APOH siRNA oligo Duplex | 100063250 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
APOH antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T86885-Ab | Human | Anti-Human APOH monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T86885-Ab | Rat | Anti-Rat APOH monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T86885-Ab | Mouse | Anti-Mouse APOH monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T86885-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque APOH monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T86885-Ab | Cat/Feline | Anti-Cat/Feline APOH monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T86885-Ab | Dog/Canine | Anti-Dog/Canine APOH monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T86885-Ab | Bovines/Cattle | Anti-Bovines/Cattle APOH monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T86885-Ab | Equine/Horse | Anti-Equine/Horse APOH monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
APOH recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T86885-Ag | Human | Human APOH recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T86885-Ag | Rat | Rat APOH recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T86885-Ag | Mouse | Mouse APOH recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T86885-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque APOH recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T86885-Ag | Cat/Feline | Cat/Feline APOH recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T86885-Ag | Dog/Canine | Dog/Canine APOH recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T86885-Ag | Bovines/Cattle | Bovines/Cattle APOH recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T86885-Ag | Equine/Horse | Equine/Horse APOH recombinant protein | Mammalian cell | Detail |