Recombinant multi-species ESR2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine ESR2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008]
The Alternative Names of target: ER-BETA,ER-beta,ERB,ERBETA,ER[b],ERbeta,ESR-BETA,ESR2,ESRB,ESTRB,Erb,Erb2,Esr2,Estrb,Estrogen receptor beta,NR3A2,Nuclear receptor subfamily 3 group A member 2,ODG8,er

Target products collectionGo to ESR2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T80896-Ag-1/ GM-Tg-hg-T80896-Ag-2 Human ESR2 protein Human
GM-Tg-rg-T80896-Ag-1/ GM-Tg-rg-T80896-Ag-2 Rat ESR2 protein Rat
GM-Tg-mg-T80896-Ag-1/ GM-Tg-mg-T80896-Ag-2 Mouse ESR2 protein Mouse
GM-Tg-cynog-T80896-Ag-1/ GM-Tg-cynog-T80896-Ag-2 Cynomolgus/Rhesus macaque ESR2 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T80896-Ag-1/ GM-Tg-felg-T80896-Ag-2 Feline ESR2 protein Feline
GM-Tg-cang-T80896-Ag-1/ GM-Tg-cang-T80896-Ag-2 Canine ESR2 protein Canine
GM-Tg-bovg-T80896-Ag-1/ GM-Tg-bovg-T80896-Ag-2 Bovine ESR2 protein Bovine
GM-Tg-equg-T80896-Ag-1/ GM-Tg-equg-T80896-Ag-2 Equine ESR2 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T80896-Ag-1/ GM-Tg-hg-T80896-Ag-2; GM-Tg-rg-T80896-Ag-1/ GM-Tg-rg-T80896-Ag-2;
GM-Tg-mg-T80896-Ag-1/ GM-Tg-mg-T80896-Ag-2; GM-Tg-cynog-T80896-Ag-1/ GM-Tg-cynog-T80896-Ag-2;
GM-Tg-felg-T80896-Ag-1/ GM-Tg-felg-T80896-Ag-2; GM-Tg-cang-T80896-Ag-1/ GM-Tg-cang-T80896-Ag-2;
GM-Tg-bovg-T80896-Ag-1/ GM-Tg-bovg-T80896-Ag-2; GM-Tg-equg-T80896-Ag-1/ GM-Tg-equg-T80896-Ag-2
Products Name ESR2 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name ESR2
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine ESR2 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.