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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Introcelluar Protein.
This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T80896
|
| Target Name |
ESR2
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
2100
|
| Gene ID |
100033964 (Equus caballus), 101086317 (Felis catus), 13983 (Mus musculus), 2100 (Homo sapiens) 25149 (Rattus norvegicus), 281146 (Bos taurus), 403639 (Canis lupus familiaris), 574110 (Macaca mulatta)
|
| Target Alternative Names |
ER-BETA,ER-beta,ERB,ERBETA,ER[b],ERbeta,ESR-BETA,ESR2,ESRB,ESTRB,Erb,Erb2,Esr2,Estrb,Estrogen receptor beta,NR3A2,Nuclear receptor subfamily 3 group A member 2,ODG8,er
|
| Uniprot Accession |
O08537,Q92731,Q62986,Q9XSB5,Q9TTE5
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
Endocrine resistance, Prolactin signaling pathway, GnRH secretion, Pathways in cancer, Chemical carcinogenesis - receptor activation, Breast cancer
|
| Gene Ensembl |
ENSECAG00000024947, ENSMUSG00000021055, ENSG00000140009, ENSBTAG00000004498, ENSCAFG00845001856, ENSMMUG00000022839
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of ESR2 cDNA Clones/ORF Plasmid
ESR2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo2100 | Pre-made Human ESR2/Erb/ESRB siRNA oligo Duplex | 2100 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25149 | Pre-made Rat Esr2/Erb2/ERbeta siRNA oligo Duplex | 25149 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo13983 | Pre-made Mouse Esr2/ER[b]/Estrb siRNA oligo Duplex | 13983 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo574110 | Pre-made Cynomolgus/Rhesus macaque ESR2 siRNA oligo Duplex | 574110 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101086317 | Pre-made Cat/Feline ESR2 siRNA oligo Duplex | 101086317 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo403639 | Pre-made Dog/Canine ESR2/ERBETA siRNA oligo Duplex | 403639 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo281146 | Pre-made Bovines/Cattle ESR2/ERB siRNA oligo Duplex | 281146 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100033964 | Pre-made Equine/Horse ESR2/er siRNA oligo Duplex | 100033964 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
ESR2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T80896-Ab | Human | Anti-Human ESR2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T80896-Ab | Rat | Anti-Rat ESR2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T80896-Ab | Mouse | Anti-Mouse ESR2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T80896-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque ESR2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T80896-Ab | Cat/Feline | Anti-Cat/Feline ESR2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T80896-Ab | Dog/Canine | Anti-Dog/Canine ESR2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T80896-Ab | Bovines/Cattle | Anti-Bovines/Cattle ESR2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T80896-Ab | Equine/Horse | Anti-Equine/Horse ESR2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
ESR2 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T80896-Ag | Human | Human ESR2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T80896-Ag | Rat | Rat ESR2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T80896-Ag | Mouse | Mouse ESR2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T80896-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque ESR2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T80896-Ag | Cat/Feline | Cat/Feline ESR2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T80896-Ag | Dog/Canine | Dog/Canine ESR2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T80896-Ag | Bovines/Cattle | Bovines/Cattle ESR2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T80896-Ag | Equine/Horse | Equine/Horse ESR2 recombinant protein | Mammalian cell | Detail |