Recombinant multi-species VHL protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine VHL protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a component of a ubiquitination complex. The encoded protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. In addition to oxygen-related gene expression, this protein plays a role in many other cellular processes including cilia formation, cytokine signaling, regulation of senescence, and formation of the extracellular matrix. Variants of this gene are associated with von Hippel-Lindau syndrome, pheochromocytoma, erythrocytosis, renal cell carcinoma, and cerebellar hemangioblastoma. [provided by RefSeq, Jun 2022]
The Alternative Names of target: HRCA1,Protein G7,RCA1,VHL,VHL1,Vhl,Vhlh,pVHL,von Hippel-Lindau disease tumor suppressor

Target products collectionGo to VHL products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T80423-Ag-1/ GM-Tg-hg-T80423-Ag-2 Human VHL protein Human
GM-Tg-rg-T80423-Ag-1/ GM-Tg-rg-T80423-Ag-2 Rat VHL protein Rat
GM-Tg-mg-T80423-Ag-1/ GM-Tg-mg-T80423-Ag-2 Mouse VHL protein Mouse
GM-Tg-cynog-T80423-Ag-1/ GM-Tg-cynog-T80423-Ag-2 Cynomolgus/Rhesus macaque VHL protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T80423-Ag-1/ GM-Tg-felg-T80423-Ag-2 Feline VHL protein Feline
GM-Tg-cang-T80423-Ag-1/ GM-Tg-cang-T80423-Ag-2 Canine VHL protein Canine
GM-Tg-bovg-T80423-Ag-1/ GM-Tg-bovg-T80423-Ag-2 Bovine VHL protein Bovine
GM-Tg-equg-T80423-Ag-1/ GM-Tg-equg-T80423-Ag-2 Equine VHL protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T80423-Ag-1/ GM-Tg-hg-T80423-Ag-2; GM-Tg-rg-T80423-Ag-1/ GM-Tg-rg-T80423-Ag-2;
GM-Tg-mg-T80423-Ag-1/ GM-Tg-mg-T80423-Ag-2; GM-Tg-cynog-T80423-Ag-1/ GM-Tg-cynog-T80423-Ag-2;
GM-Tg-felg-T80423-Ag-1/ GM-Tg-felg-T80423-Ag-2; GM-Tg-cang-T80423-Ag-1/ GM-Tg-cang-T80423-Ag-2;
GM-Tg-bovg-T80423-Ag-1/ GM-Tg-bovg-T80423-Ag-2; GM-Tg-equg-T80423-Ag-1/ GM-Tg-equg-T80423-Ag-2
Products Name VHL protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name VHL
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine VHL protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.