Recombinant multi-species BMP-4/BMP4 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine BMP-4/BMP4 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates heart development and adipogenesis. Mutations in this gene are associated with orofacial cleft and microphthalmia in human patients. The encoded protein may also be involved in the pathology of multiple cardiovascular diseases and human cancers. [provided by RefSeq, Jul 2016]
The Alternative Names of target: BMP-4, BMP4,Bone morphogenetic protein 4,BMP-4,Bone morphogenetic protein 2B (BMP-2B),ZYME,BMP2B,OFC11,BMP2B1,MCOPS6

Target products collectionGo to BMP-4/BMP4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T77410-Ab-1/ GM-Tg-hg-T77410-Ab-2 Human BMP-4/BMP4 protein Human
GM-Tg-rg-T77410-Ab-1/ GM-Tg-rg-T77410-Ab-2 Rat BMP-4/BMP4 protein Rat
GM-Tg-mg-T77410-Ab-1/ GM-Tg-mg-T77410-Ab-2 Mouse BMP-4/BMP4 protein Mouse
GM-Tg-cynog-T77410-Ab-1/ GM-Tg-cynog-T77410-Ab-2 Cynomolgus/Rhesus macaque BMP-4/BMP4 monoclonal antibody Cynomolgus/ Rhesus macaque
GM-Tg-felg-T77410-Ab-1/ GM-Tg-felg-T77410-Ab-2 Feline BMP-4/BMP4 protein Feline
GM-Tg-cang-T77410-Ab-1/ GM-Tg-cang-T77410-Ab-2 Canine BMP-4/BMP4 protein Canine
GM-Tg-bovg-T77410-Ab-1/ GM-Tg-bovg-T77410-Ab-2 Bovine BMP-4/BMP4 protein Bovine
GM-Tg-equg-T77410-Ab-1/ GM-Tg-equg-T77410-Ab-2 Equine BMP-4/BMP4 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T77410-Ab-1/ GM-Tg-hg-T77410-Ab-2; GM-Tg-rg-T77410-Ab-1/ GM-Tg-rg-T77410-Ab-2;
GM-Tg-mg-T77410-Ab-1/ GM-Tg-mg-T77410-Ab-2; GM-Tg-cynog-T77410-Ab-1/ GM-Tg-cynog-T77410-Ab-2;
GM-Tg-felg-T77410-Ab-1/ GM-Tg-felg-T77410-Ab-2; GM-Tg-cang-T77410-Ab-1/ GM-Tg-cang-T77410-Ab-2;
GM-Tg-bovg-T77410-Ab-1/ GM-Tg-bovg-T77410-Ab-2; GM-Tg-equg-T77410-Ab-1/ GM-Tg-equg-T77410-Ab-2
Products Name BMP-4/BMP4 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name BMP-4/BMP4
Protein Sub-location Secreted Protein/Potential Cytokines
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine BMP-4/BMP4 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.